Ongoing clinical trials of FGFR-targeted therapy in UC
Drugs
Targets
Combination
Conditions
Phase
NCT
Erdafitinib
FGFR2/3
Null
Rec UC | FGFR3 gene mutation
II
NCT04917809
Erdafitinib
FGFR2/3
Null
UC
I
NCT05316155
Erdafitinib
FGFR2/3
Null
UC
I
NCT05567185
Erdafitinib
FGFR2/3
Gemcitabine + mitomycin C
UC
II
NCT04172675
Erdafitinib
FGFR2/3
Atezolizumab
UC | MIBC
II
NCT05564416
Erdafitinib
FGFR2/3
Enfortumab vedotin
Adv UC
I
NCT04963153
Rogaratinib
FGFR1–3
Null
UC
II
NCT04040725
Rogaratinib
FGFR 1-3
Atezolizumab
UC
I
NCT03473756
Pemigatinib
FGFR1–3
Null
Rec UC | NMIBC
II
NCT03914794
Infigratinib
FGFR1–3
Null
Solid Tumor
II
NCT05019794
Infigratinib
FGFR1–3
Null
Adv/Met malignant solid neoplasm
II
NCT04233567
Infigratinib
FGFR1–3
Null
Adv solid tumor
I/II
NCT05222165
Infigratinib
FGFR1–3
Null
UC | NMIBC
Not applicable
NCT02657486
Futibatinib
FGFR1–4
Null
UC
I/II
NCT02052778
ICP-192
FGFR 1–4
Null
UC
II
NCT04492293
ICP-192
FGFR 1–4
Null
UC
I/II
NCT04565275
TYRA-300
FGFR3
Null
UC
I
NCT05544552
Null in Combination indicates that the trial is monotherapy. FGFR: fibroblast growth factor receptor; UC: urothelial carcinoma; MIBC: muscle-invasive bladder cancer; NMIBC: non-MIBC; Adv: advanced; Met: metastatic; Rec: recurrent; NCT: national clinical trial; ICP-192: gunagratinib; |: and
Declarations
Author contributions
SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.
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