Ongoing clinical trials of ErbB-targeted therapy in UC
Drugs
Targets
Combination
Conditions
Phase
NCT
Afatinib
ErbB-1/2 (EGFR/ HER2)
Null
Adv UC
II
NCT02122172
Afatinib
ErbB-1/2 (EGFR/ HER2)
Null
Adv solid tumors
II
NCT02465060
Cetuximab
ErbB-1 (EGFR)
TTX-080
Cancer
I
NCT04485013
Cetuximab
ErbB-1 (EGFR)
SNK01
UC
I/II
NCT04464967
Lapatinib
ErbB-1/2 (EGFR/ HER2)
Null
UC
II/III
NCT00949455
Lapatinib
ErbB-1/2 (EGFR/ HER2)
Paclitaxel
UC
II
NCT01700010
Trastuzumab deruxtecan
ErbB-2 (HER2)
Null
UC
II
NCT04482309
Trastuzumab deruxtecan
ErbB-2 (HER2)
Nivolumab
UC
I
NCT03523572
Trastuzumab deruxtecan
ErbB-2 (HER2)
Pyrotinib
Met/Adv UC, HER2 positive
II
NCT05318339
Trastuzumab deruxtecan
ErbB-2 (HER2)
Tucatinib
Urologic neoplasms
II
NCT04579380
Trastuzumab deruxtecan
ErbB-2 (HER2)
AZD5305
UC
I/II
NCT04644068
RC48-ADC
ErbB-2 (HER2)
Null
UC | NMIBC
II
NCT05996952
RC48-ADC
ErbB-2 (HER2)
Toripalimab
UC | MIBC
II
NCT05297552
RC48-ADC
ErbB-2 (HER2)
Triplizumab
UC | MIBC, HER2 positive
II
NCT05356351
RC48-ADC
ErbB-2 (HER2)
Triplizumab
UC
II
NCT05016973
RC48-ADC
ErbB-2 (HER2)
Toripalimab
UC | MIBC, HER2 positive
II
NCT05979740
RC48-ADC
ErbB-2 (HER2)
pembrolizumab
UC
II
NCT04879329
RC48-ADC
ErbB-2 (HER2)
pembrolizumab
UC
III
NCT05911295
Trastuzumab emtansine
ErbB-2 (HER2)
Null
UC
II
NCT02675829
Null in combination indicates that the trial is monotherapy. ErbB: erythroblastic oncogene B; EGFR: epidermal growth factor receptor; HER2: human epidermal growth factor receptor 2; MIBC: muscle-invasive bladder cancer; NMIBC: non-MIBC; UC: urothelial carcinoma; Adv: advanced, Met: metastatic, Rec: recurrent; RC48-ADC: disitamab vedotin; NCT: national clinical trial
Declarations
Author contributions
SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.
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