Ongoing clinical trials of VEGF-targeted therapy in UC
Drugs
Targets
Combinations
Conditions
Phase
NCT
Bevacizumab
VEGF
MK-7684A
UC
II
NCT05007106
Bevacizumab
VEGF
Dasatinib
Met/Adv UC
I
NCT04164069
Lenvatinib
VEGFR1–3
GI-101
Met/Adv UC
I/II
NCT04977453
Lenvatinib
VEGFR1–3
MK-7684A
UC
II
NCT05007106
Ramucirumab
VEGFR2
TRK-950
UC
I
NCT03872947
VEGF: vascular endothelial growth factor; UC: urothelial carcinoma; VEGFR1–3: vascular endothelial growth factor receptor 1–3; Adv: advanced; Met: metastatic; MK-7684A: the combination of vibostolimab and pembrolizumab; GI: SIM0323
Declarations
Author contributions
SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.
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