Ongoing clinical trials of PI3K/Akt/mTOR and MAPK pathway-targeted therapy in UC
Drugs
Taegets
Combination
Conditions
Phase
NCT
Copanlisib
PI3Kα/δ
Avelumab
Adv UC
I/II
NCT05687721
Ipatasertib
Akt
Null
Adv UC
II
NCT02465060
Sapanisertib
mTOR1/2
Null
Adv UC
II
NCT03047213
Tipifarnib
RAS
Null
UC
II
NCT02535650
Sorafenib
RAF
gemcitabine and cisplatin
UC
II
NCT01222676
Vistusertib
mTOR
Null
UC | MIBC
I
NCT02546661
Null in combination indicates that the trial is monotherapy. MAPK: mitogen-activated protein kinase; UC: urothelial carcinoma; PI3K: phosphatidylinositol 3-kinas; Akt: protein kinase B; mTOR: mammalian target of rapamycin; MIBC: muscle-invasive bladder cancer; Adv: advanced; RAS: sat sarcoma; RAF: rapidly accelerated fibrosarcoma; NCT: National Clinical Trial; |: and
Declarations
Author contributions
SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.
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