Ongoing clinical trials of PARP-targeted therapy in UC
Drugs
Targets
Combinations
Conditions
Phase
NCT
Niraparib
PARP
Dostarlimab
UC
II
NCT04779151
Niraparib
PARP
Atezolizumab
UC
I/II
NCT03869190
Olaparib
PARP
Null
Met/Adv UC
II
NCT03375307
Olaparib
PARP
EP0057
UC
I/II
NCT02769962
Olaparib
PARP
Durvalumab
UC | MIBC
I
NCT02546661
Olaparib
PARP
Ceralasertib
Met UC
II
NCT03682289
Talazoparib
PARP
Avelumab
UC
II
NCT04678362
Veliparib
PARP
Paclitaxel, carboplatin
UC
I
NCT01366144
Null in combination indicates that the trial is monotherapy. PARP: poly ADP-ribose polymerase; MIBC: muscle-invasive bladder cancer; UC: urothelial carcinoma; Adv: advanced; Met: metastatic. |: and
Declarations
Author contributions
SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.
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