FDA approval of rituximab for use against B-cell malignancies [24, 25]

CD20 positive B-NHLCLL
Single agent to treat relapsed/refractory, low grade, or follicular B cell NHLCombination with fludarabine and cyclophosphamide
Single agent therapy for those who achieve a complete or some degree of response to combination chemotherapy
Single agent in low grade stable B cell NHL after CVP chemotherapy
Combination with anthracycline-based chemotherapy in untreated DLBCL

B-NHL: B cell non-Hodgkin’s lymphoma; CLL: chronic lymphocytic leukemia; DLBCL: diffuse-large B cell lymphoma