The first approval of ADCs as a single agent by the Food and Drug Administration (FDA) and/or European Medicines Agency (EMA)

DrugTargetIndicationFDA/EMAApproval yearSponsor
Gemtuzumab ozogamicinCD33AMLy/y2000; 2017Pfizer/Wyeth
Brentuximab vedotinCD30HLy/y2011Seattle Genetics
Trastuzumab emtansineHER2HER2-positive mBCy/y2013Genetech/Roche
Inotuzumab ozogamicinCD22Acute lymphoblastic leukemiay/y2017Pfizer/Wyeth
Moxetumomab pasudotoxCD22HCLy/y–withdrawn2018–withdrawn in July 2023AstraZeneca
Enfortumab vedotinNectin-4Urothelial cancery/y2019Astellas/Seattle Genetics
Trastuzumab deruxtecanHER2HER2-positive mBCy/y2019AstraZeneca/Daiichi Sankyo
Sacituzumab govitecanTrop-2Metastatic TNBCy/y2020Immunomedics
Belantamab mafodotinBCMAMultiple myelomay/y–withdraw process2020–withdraw process in November 2022GlaxoSmithKline
Loncastuximab tesirineCD19DLBCLy/y2021ADC Therapeutics
Tisotumab vedotin-tftvTissue factorRecurrent or metastatic cervical cancery/n2021Seagen Inc
Mirvetuximab soravtansineFRαFRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or peritoneal cancery/y2022ImmunoGen

ADCs: antibody-drug conjugates; AML: acute myeloid leukemia; HCL: hairy-cell leukemia; HL: Hodgkin lymphoma; HER2: human epidermal growth factor receptor 2; mBC: metastatic breast cancer; Nectin-4: nectin cell adhesion molecule 4; Trop-2: trophoblast cell surface antigen-2; TNBC: triple-negative breast cancer; BCMA: B cell maturation antigen; DLBCL: diffuse large B-cell lymphoma; FRα: folate receptor alpha; n: not; y: yes