Table Info

Table 2.

Immune checkpoint inhibitors + EGFR-TKI therapy

Study name	Setting	Drugs	Phase	Efficacy	AEs	References
CheckMate012	≥ 2nd	Nivolumab and erlotinib	Ib	ORR 15%, DCR 65%, PFS: 5.1 months	G3: 24%, no G4 or G5 TRAEs	[49]
TATTON	≥ 2nd	Durvalumab + osimertinib	Ib	ORR 43%	≥ G3: 48%; ILD occurred in 22% (≥ G3, 8.7%)	[14]
CAURAL	≥ 2nd	Durvalumab + osimertinib	III	ORR 64% in the combination arm	Not sufficient data, grade 2 interstitial lung disease occurred in 1 patient.	[46]
NCT02040064	2nd	Tremelimumab and gefitinib	I	PFS of 2.2 months	G3 TRAE 81%	[50]
NCT01998126	1st	Ipilimumab and erlotinib	I	PFS 27.8 months	Four of the 11 patients had G3 colitis.	[51]
NCT02013219	1st and any	Atezolizumab + erlotinib	Ib	PFS 15.4 months	G3 46%, no G4 or G5 TRAE.	[52]
KEYNOTE 021	1st	Pembrrolizumab + gefitinib (cohort F), Pembrrolizumab + erlotinib (cohort E)	Phase I/II	ORR 41.7% in cohort F and 14.3% in cohort E	G3: 33.3% in cohort F, G3–4: 71.4% in cohort E	[44]

ORR: objective response rate; DCR: dacryocystorhinostomy; PFS: progression free survival; TRAEs: treatment related adverse event; ILD: interstitial lung disease; EGFR: epidermal growth factor receptor; TKI: tyrosine kinase inhibitor

Declarations

Author contributions

KA, TS, AI, TH, YG, NH, and MK: Writing—review & editing. KI: Writing—review & editing, Supervision. YO: Conceptualization, Data curation, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

YO reports personal fees from Bristol Myers Squibb, Eli Lilly, Takeda, Daiichi Sankyo, AstraZeneca, Chugai Pharma, Amgen, and Novartis, and personal fees from Taiho outside the submitted work. YG reports personal fees from Bristol Myers Squibb, Eli Lilly, Takeda, AstraZeneca, Chugai Pharma, Taiho, and Boehringer Ingelheim outside the submitted work. NH received a research grant from Boehringer Ingelheim and lecture fees from GlaxoSmithKline, AstraZeneca, Novartis, and Boehringer Ingelheim, outside the submitted work. MK received personal fees from Bristol Myers Squibb, Eli Lilly, Takeda, Daiichi Sankyo, AstraZeneca, Chugai Pharma, MSD, and Taiho outside the submitted work. KI reports personal fees from GSK, MSD, Sanofi, AstraZeneca, and Chugai Pharmaceutical Co., and he received research grants from Chugai Pharmaceutical Co. and Taiho Pharmaceutical Co. The other authors declare that they have no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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