Grading of liver biochemical test derangement
| Liver enzyme | Baseline level | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
| Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) | If baseline normal | > ULN to 3× ULN | > 3–5× ULN | > 5–20× ULN | > 20× ULN |
| If baseline abnormal | 1.5–3× baseline | > 3–5× baseline | > 5–20× baseline | > 20× baseline | |
| Alkaline phosphatase (ALP) | If baseline normal | > ULN to 2.5× ULN | > 2.5–5× ULN | > 5–20× ULN | > 20× ULN |
| If baseline abnormal | 2–2.5× baseline | > 2.5–5× baseline | > 5–20× baseline | > 20× baseline | |
| Bilirubin | If baseline normal | > ULN to 1.5× ULN | > 1.5–3× ULN | > 3–10× ULN | > 10× ULN |
| If baseline abnormal | > 1–1.5× baseline | > 1.5–3× baseline | > 3–10× baseline | > 10× baseline |
ULN: upper limit of normal
