General characteristics of studies on the role of NLR in tCa staging

ReferenceSample sizeStudy designYear of publicationCountryHistopathologyCut off value of NLRSeminomatous tCaOutcome
Gokcen et al. [33]121Retrospective cohort2018TurkeyTGCT2.25-No significant difference was found between patients in different stages according to their NLR values.
Şahin et al. [47]291Cross-sectional retrospective2019TurkeytCa3.16-There was no association between NLR and different tumor stages.
Arda et al. [26]182Retrospective cohort2020TurkeyTGCT1.7846.60%Tumor stage was not different between patients with different values of NLR.
Horsanali et al. [36]128Retrospective cohort2017TurkeyTGCT3.7244.80%No significant correlation was found between NLR value and tumor stage.
Yıldırım et al. [52]21Retrospective
cohort		2013TurkeytCa -47.61%There was no significant correlation between NLR and tCa staging.
Kölükçü et al. [41]17Retrospective cohort2017TurkeytCa-17.64%The NLR value was not different between different tumor stages.
Imamoglu et al. [4]112Retrospective cohort2019TurkeyTGCT3.2158.92%There was a significant difference in NLR between stage I and advanced stages.
Jankovich et al. [38]103Retrospective cohort2017SlovakiaTGCT439.80%There was a significant correlation between NLR and tumor stage.
Karakaya et al. [39]40Retrospective cohort2021TurkeyTGCT-22.50%Statistically significant positive correlations were found between tumor stage and NLR.
Olcucu et al. [44]99Retrospective cohort2020TurkeyTGCT3.2145.45%Patients with advanced-stage cancer had higher values of NLR in comparison with those in lower stages.
Pęksa et al. [45]180Retrospective cohort2021PolandTGCT3.5653.90%NLR was significantly higher in patients with stage II/III tumors compared to those with stage I.
Tan et al. [2]160Retrospective cohort2019SingaporetCa363.80%Patients with advanced stages had higher values of NLR than those in lower stages.

tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio