Table Info

Table 5.

General characteristics of studies on the association of NLR with nodal or distant metastases in tCa

Reference	Sample size	Study design	Year of publication	Country	Histopathology	Cut off value of NLR	Seminomatous tCa	Outcome
Yigit et al. [51]	146	Retrospective cohort	2018	Turkey	tCa	3.11	36.30%	High level of NLR was associated with the risk of metastasis.
Bolat et al. [29]	53	Retrospective cohort	2017	Turkey	TGCT	3.35	50.90%	Elevated NLR could predict lymph node involvement.
Ilktac et al. [37]	61	Retrospective cohort	2020	Turkey	TGCT	2.56	59.00%	NLR was significantly higher in patients with non-localized TGCT compared to those with localized TGCT.
Horsanali et al. [36]	128	Retrospective cohort	2017	Turkey	TGCT	3.72	44.80%	Elevated NLR was significantly related to metastasis.
Köşeci et al. [43]	72	Retrospective cohort	2021	Turkey	TGCT	2.5	43.00%	Elevated NLR could predict metastasis.
Pęksa et al. [45]	180	Retrospective cohort	2021	Poland	TGCT	3.56	53.90%	Elevated NLR could predict the presence of nodal or distant metastases.
Bauzá Quetglas et al. [46]	80	Retrospective cohort	2020	Spain	tCa	2.25	62.50%	NLR had higher levels in patient with non-localized tCa than those with localized tCa.
Olcucu et al. [44]	99	Retrospective cohort	2020	Turkey	TGCT	3.21	45.45%	Elevated NLR could predict metastasis and low mean survival time.
Tan et al. [2]	160	Retrospective cohort	2019	Singapore	tCa	3	63.80%	High levels of NLR were associated with metastasis and poorer CSS.
Arda et al. [26]	182	Retrospective cohort	2020	Turkey	TGCT	1.78	46.60%	There was no significant association between metastasis with NLR of patients.
Jankovich et al. [38]	103	Retrospective cohort	2017	Slovakia	TGCT	4	39.80%	No significant correlation was found between metastasis with NLR.
Kopru et al. [42]	80	Retrospective cohort	2019	Turkey	tCa	-	51.51%	NLR had no statistically significant correlation with metastasis and the presence of lymphovascular invasion.
Başer and Aras [28]	83	Retrospective cohort	-	Turkey	TGCT	2.27	60.00%	There was no significant association between NLR and metastasis or lymph node involvement.

tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio

Declarations

Author contributions

SS: Conceptualization. SB: Investigation, Writing—original draft. SK: Conceptualization, Writing—review & editing. AS: Investigation. AC: Investigation. DK: Writing—original draft. MK: Writing—review & editing. AG: Writing—review & editing. BLW: Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Datasets are available on request.

Funding

Not applicable.

Copyright

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