General characteristics of studies on the association of NLR with survival in tCa

ReferenceSample sizeStudy designYear of publicationCountryHisto
pathology		Cut off value of NLRSeminomatous tCa
Outcome
Arıman and Merder [27]152Retrospective cohort2021TurkeytCa2.3952.60%Patients with good prognosis had statistically significant lower NLR than those with intermediate and poor prognosis.
Tan et al. [2]160Retrospective cohort2019SingaporetCa363.80%High levels of NLR were associated with poorer CSS.
Fankhauser et al. [31]146Retrospective cohort2018SwitzerlandTGCT4.525.34%NLR was an independent predictor of OS.
Olcucu et al. [44]99Retrospective cohort2020TurkeyTGCT3.2145.45%Elevated NLR could predict metastasis and low mean survival time.
Herraiz-Raya et al. [35]164Retrospective cohort2019SpainTGCT450.00%There was significant correlation between NLR and residual disease after chemotherapy and mean survival time of tCa patients.
Yang et al. [50]2008–2016Retrospective
cohort		2019ChinatCa2.66-High NLR was significantly associated with an elevated risk for disease progression.
Karakaya et al. [39]40Retrospective
cohort		2021TurkeyTGCT-22.50%NLR was a strong predictor of response to chemotherapy in tCa patients.
Bauzá Quetglas et al. [46]80Retrospective cohort2020SpaintCa2.2562.50%Pre-orchiectomy NLR was higher in patients who had adjuvant chemotherapy than those without chemotherapy.
Post-orchiectomy NLR was related to the risk of recurrence and recurrence-free survival.
Selvi and Başar [49]99Retrospective cohort2019TurkeytCa3.2360.00%NLR was found to be significantly higher in patient with bilateral tCa than those with unilateral tCa. High NLR could predict contralateral tumor development.
Arda et al. [26]182Retrospective cohort2020TurkeyTGCT1.7846.60%CSS was not different between patients with different NLR.
Yoshinaga et al. [53]63Retrospective cohort2021JapanTGCT4.127.00%There was no significant association between PFS and OS and NLR.
Pęksa et al. [45]180Retrospective cohort2021PolandTGCT3.5653.90%NLR could not predict progression or relapse in tCa patients.
Bolat et al. [29]53Retrospective cohort2017TurkeyTGCT3.3550.90%Time-to-cancer specific death between patients with different NLR was not significantly different.

tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio; CSS: cancer-specific survival; OS: overall survival; PFS: progression-free survival