Table Info

Table 2.

Inflammatory routine laboratory derived scores and association with outcomes to immunotherapy in RCC

Candidate biomarker	References	Year	Country	N	Tumor	Timepoint	Type of systemic therapy	Cut-off/Trend indicator	Findings
NLR	Bilen et al. [39]	2022	US	886	RCC	Pretreatment	Avelumab plus axitinib or sunitinib	High	Worse OS and PFS
NLR	Simonaggio et al. [42]	2020	France	161	RCC and NSCLC	On-treatment changes	Nivolumab	Increase	Worse OS and PFS
NLR	Young et al. [43]	2024	UK	132	RCC	Pretreatment On-treatment changes	ICI combinations	≥ 3 at baseline	NS trend for worse OS
								≥ 3 at 12 weeks	Worse OS
								Normalization of pre-treatment elevation	Superior OS and ORR
NLR	Ishihara et al. [136]	2019	Japan	58	RCC	Pretreatment	Nivolumab	≥ 3	Worse OS after MVA, worse PFS only on UVA
NLR	Suzuki et al. [137]	2020	Japan	65	RCC	Pretreatment	Nivolumab	≥ 5	Worse OS
NLR	Shirotake et al. [138]	2019	Japan	54	RCC	Pretreatment	Nivolumab	≥ Median value (2.89)	NS
NLR	Zahoor et al. [54]	2018	US	90	RCC	Pretreatment	Nivolumab	≥ 4.2	Worse PFS
NLR	Tucker et al. [56]	2021	US	110	RCC	Pretreatment	Nivolumab plus ipilimumab	≥ 3.42	Worse OS
LIPI	Meyers et al. [47]	2019	Canada	643	NSCLC, melanoma and RCC (145, 25%)	Pretreatment	ICI	Good LIPI, 0 factor	No difference in OS, PFS or ORR between the good and intermediate LIPI groups
								Intermediate LIPI, 1 factor
								Poor LIPI, 2 factors	Worse OS and PFS
LIPI	Carril-Ajuria et al. [48]	2024	France	1,084	ccRCC	Pretreatment	Nivolumab plus ipilimumab vs. sunitinib	Intermediate/Poor LIPI (1–2 factors) vs. good LIPI (0 factor)	Worse OS in both treatment arms
NER	Zhuang et al. [139]	2023	US	184	RCC	Pretreatment	ICI	High NER > 49.2	Worse OS No significant difference for PFS
NER	Tucker et al. [56]	2021	US	110	RCC	Pretreatment	Nivolumab plus ipilimumab	≥ Median value 26.4	Worse PFS, OS and ORR
PLR	Iinuma et al. [59]	2021	Japan	43	RCC	Pretreatment	Nivolumab plus ipilimumab	High Median 215.6	Poor PFS
SII	Iinuma et al. [59]	2021	Japan	43	RCC	Pretreatment	Nivolumab plus ipilimumab	Median SII of 730	Improved survival in the SII low

ccRCC: clear cell renal cell carcinoma; ICI: immune checkpoint inhibitors; LIPI: lung immune prognostic index; MVA: multivariate; UVA: univariate; NER: neutrophil-to-eosinophil ratio; NLR: neutrophil-to-lymphocyte ratio; NS: non-significant; NSCLC: non-small cell lung cancer; ORR: objective response rate; OS: overall survival; PFS: progression-free survival; PLR: platelet-to-lymphocyte ratio; RCC: renal cell carcinoma; SII: systemic immune inflammation; UC: urothelial carcinoma; UK: United Kingdom; US: United States. Meta-analysis not included

Declarations

Author contributions

LO: Conceptualization, Investigation, Writing—original draft. MN: Visualization. RF, JGD, JPF, DN, CA, AAS, NC, GdV, and LA: Writing—review & editing. LCA: Conceptualization, Investigation, Writing—original draft.

Conflicts of interest

RF: Honoraria: Bayer, Astellas, Janssen, BMS, MSD, Ipsen, Pfizer, Merck, Astra Zeneca. NC has provided expertise through participation in scientific advisory boards to AstraZeneca and to Servier and received a research grant from Cytune Pharma, Roche, and Sanofi, although these grants were not on the matter of this manuscript. GdV: grants and personal fees from Pfizer, Roche, and Ipsen; and personal fees from Bristol-Myers Squibb, Astellas, Janssen, Bayer, Merck, and MSD. LA: Consulting or Advisory Role: Astellas Pharma (Inst), Bristol:Myers Squibb (Inst), Eisai (Inst), Ipsen (Inst), Janssen (Inst), MSD (Inst), Pfizer (Inst), Roche (Inst). Travel, Accommodations, Expenses: BMS, Ipsen, MSD. LCA: Travel/accomodation: Pfizer, Ipsen, BMS. Honoraria: Ipsen, Janssen. The rest of authors declare no competing interests.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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