Table Info

Table 2.

Bispecific antibodies

Target	Drug	Trial, phase	Outcomes
c-Met/EGFR	Amivantamab	CHRYSALIS [68] N = 45, osimertinib-relapsed EGFRm Phase 1/1B	ORR 36% DOR 9.6 mo mPFS 4.9 mo
c-Met/EGFR	Amivantamab	MARIPOSA-2 [76] (CT vs. plus CT vs. plus lazertinib-CT) N = 263 vs. 131 vs. 263 Phase 3	CT alone vs. plus CT vs. plus Lazertinib-CT: ORR 36% vs. 64% vs. 63% DOR 5.6 vs. 6.9 vs. 9.4 mo mPFS 4.2 vs. 8.2 vs. 8.3 mo
PD-L1/VEGF	Ivonescimab (AK112)	NCT05184712 [77] (AK112 vs. CT) N = 161 vs. 161 Phase 3	AK112 vs. CT: mPFS 7.1 mo vs. 4.8 mo
HER3/EGFR	BL-B01D1	NCT05194982 [78] (EGFR-WT vs. EGFRm) N = 50 vs. 38 Phase 1 (ongoing)	EGFR-WT vs. EGFRm: ORR 44% vs. 63.2% mPFS 5.2 mo vs. 6.9 mo (immature) DCR 94% vs. 89.5%
HER3/EGFR	Izalontamab (SI-B001)	NCT05020457 [79] N = 45, SI-B001 plus doecetaxel Phase 2 (ongoing)	ORR 31.3% DCR 77.1%

ORR: overall response rate; DOR: duration of response; mPFS: median progression-free survival; DCR: disease control rate; EGFRm: EGFR-mutated; EGFR-WT: EGFR wild type; CT: chemotherapy; HER3: human epidermal growth factor receptor 3

Declarations

Author contributions

KW: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Validation. AL: Conceptualization, Investigation, Writing—original draft, Validation. RH: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Validation, Supervision.

Conflicts of interest

RH is a consultant for Targeted Oncology and Takeda and received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group. Both other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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