Table Info

Table 3.

Clinical trial data and ongoing trials testing novel treatments in NSCLC

Type	Drug	Trial	Outcomes	Phase/No.
CAR-T	EGFR-targeting CAR-T, modified by CXCR5	NCT05060796, NCT04153799		1 (n = 11), 1 (n = 11)
	EGFR-targeting CAR-T, knocked-out TGFβ receptor	NCT04976218		1 (n = 30)
	MSLN-targeting CAR-T plus anti-PD-1 cells (for mesothelioma)	NCT04577326		1 (n = 30)
	MSLN-targeting CAR-T	NCT04489862		1 (n = 10)
	PSCA/MUC1/TGFβ/GPC3-targeting CAR-T	NCT03198052		1 (n = 30)
	MUC1-targeting CAR-T plus anti-PD-1 cells	NCT03525782		1/2 (n = 60)
	MUC1-targeting CAR-T, 3 + 3 dose design	NCT05239143		1 (n = 100)
TCR	KK-LC1-targeting TCR, followed by high dose IL-2	NCT05483491, NCT03778814		1 (n = 42), 1 (n = 30)
	MAGE A4/8-targeting TCR	NCT03247309		1 (n = 7)
	MAGE A10-targeting TCR	NCT02592577 [83]	11% PR 36% SD	1 (n = 11)
	Neoantigen-targeting TCR (NSCLC not specified)	NCT03412877		2 (n = 270 total)
	NY-ESO-1 targeting TCR, followed by low dose IL-2	NCT02457650 [84]	25% PR 25% SD	1 (n = 4)
	NY-ESO-1 targeting TCR	NCT05296564		1 (n = 3)
	KRAS, EGFR, TP53 targeting TCR; followed by IL-2 (NSCLC not specified)	NCT05194735		1/2 (n = 180 total)
mRNA	CEA-targeting RNA-pulsed DCs (NSCLC not specified)	NCT00004604 [85]	4% CR 8% PR 12% SD	1 (n = 24)
	SOCS1, MUC1, survivin-targeting RNAs	NCT02688686		1/2 (n = 30)
	KRAS-targeting RNA	NCT03948763, NCT05202561		1 (n = 70), 1 (n = 10)
	NY-ESO-1, MAGEC1/C2, survivin, trophoblast-targeting RNAs (CV9201)	NCT00923312 [86]	31% SD 69% PD mPFS 5.0 mo mOS 10.8 mo	1/2 (n = 46)
	NY-ESO-1, MAGEC1/C2, MUC1, survivin, 5T4 RNAs (CV9202 or BI1361849)	NCT03164772 [87] (Arm A: mRNA plus durvalumab; Arm B mRNA plus durvalumab plus tremelimumab)	Arm A: ORR 29% Arm B: ORR 11%	1/2 (n = 62)
		NCT01915524 [88]	4% PR (with pemetrexed) 46.2% SD	1 (n = 26) Terminate
	Personalized neoantigen mRNA	NCT03908671		1 (n = 24)

CAR: chimeric antigen receptor; TCR: T-cell receptor therapy; ORR: overall response rate; mPFS: median progression-free survival; mOS: median overall survival; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; GPC3: phosphatidylinositol proteoglycan 3; MUC1: mucin 1; NSCLC: non-small cell lung cancer; PSCA: prostate stem cell antigen

Declarations

Author contributions

KW: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Validation. AL: Conceptualization, Investigation, Writing—original draft, Validation. RH: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Validation, Supervision.

Conflicts of interest

RH is a consultant for Targeted Oncology and Takeda and received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group. Both other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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