Table Info

Table 3.

Overview on various biomarkers in liquid biopsy for MPM

Author	Biomarker	Study design	Samples	Role
Santarelli et al. 2015 [78]	Methylated TM	MPM = 45; AES = 99; HS = 44	Serum	Diagnosis: MPM vs. controls (sensitivity 60%, specificity 81%)
Sriram et al. 2014 [91]	DNA integrity index (+ citology)	MPE = 52; OPE = 23	Pleural effusion	Diagnosis: MPM vs. OPE (sensitivity 81%, specificity 87%)
Yoneda et al. 2019 [97]	Podoplanin	MPM = 15	Blood	Diagnosis: CTC-chip vs. CellSearch (sensitivity 63.3%–64.5%); prognosis

TM: thrombomodulin

Declarations

Author contributions

GV designed the paper and wrote the manuscript. DDN co-wrote the manuscript. MB and RL reviewed the literature. MF, ADT and GG provided critical revision of the article. All authors read and approved the submitted version.

Conflict of interests

The authors declare that they have no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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