Table Info

Table 1.

Benefits and limitations of ctDNA-based technology for the assessment of immunotherapy response

Benefits	Limitations
Reduction in ctDNA levels associated with overall survival and progression-free survival	Comorbidities can affect ctDNA levels (smoking, pregnancy, heart disease, inflammation)
Detection of immunotherapy response after about 8 weeks	Clonal hematopoiesis
Allows for serial monitoring to detect developing resistance and genomic variants	Variable ctDNA fraction based on primary malignancy and stage
Non-invasive detection (blood test)	Multiple assays to choose from with no standardization
Comprehensive, patient-specific molecular profiling	Wide variability in cost
-	Concordance between aberrations detected in ctDNA and tumor tissue
-	Low concentration and fragmentation
-	Unable to detect genomic fusion events and copy number changes

ctDNA: circulating tumor DNA; -: no data

Declarations

Author contributions

BJH and JB: Conceptualization, Writing—original draft, Writing—review & editing. Both authors read and approved the submitted version.

Conflicts of interest

Both authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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