Selected ongoing phase III trials evaluating neoadjuvant, perioperative, and adjuvant chemoimmunotherapy in resectable NSCLC
Trial
Patient population
Treatment
Primary endpoint
Study completion
MERMAID-1 (NCT04385368)
Stage II/III NSCLC after resection
Adjuvant durvalumab or placebo plus chemotherapy for 12 weeks followed by durvalumab or placebo for up to week 48
DFS in the MRD+ (measured by whole exome sequencing-based ctDNA test) group
2023-8-31
ANVIL (NCT02595944)
Stage IB (≥ 4 cm)–IIIA NSCLC after resection
Adjuvant nivolumab or observation
OS and DFS
2025-12-31
LungMate-008 (NCT04772287)
Stage II–IIIB (N2) NSCLC after resection
Adjuvant toripalimab or placebo with chemotherapy followed by 4 cycles adjuvant toripalimab or placebo
DFS
2027-12-30
ADOPT-lung (NCT06284317)
Resectable IIB–IIIB (N2)
Adjuvant durvalumab for 12 cycles or observation
DFS
2030-03
NADIM-ADJUVANT (NCT04564157)
Stage IB–IIIA NSCLC after resection
Adjuvant nivolumab with chemotherapy followed by 6-month of nivolumab vs. adjuvant chemotherapy
DFS
2031-04-01
IMpower 030 (NCT03456063)
Resectable stage II, IIIA, or select IIIB
Four cycles of neoadjuvant atezolizumab with chemotherapy and up to 16 cycles of adjuvant atezolizumab or placebo with chemotherapy
EFS
2025-01-19
PROSPECT LUNG (NCT06632327)
Resectable stage IIA to IIIB
Neoadjuvant ICI with 4 cycles of chemotherapy and one year adjuvant ICI vs. adjuvant therapy with 4 cycles chemotherapy and one year ICI
3-year real-world event-free survival (rwEFS) and OS
2030-04-30
CLEAR-INSIGHT (INSIGHT: NCT06498635)
Stage II–IIIB after resection
SOC neoadjuvant platinum-based chemotherapy and anti-PD-(L)1 therapy then surgerypCR: adjuvant durvalumab for 12 cycles vs. observation (INSIGHT)Non-pCR: adjuvant durvalumab and novel inhibitor combination vs. durvalumab for one year
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