Selected ongoing phase III trials utilizing immunotherapy in unresectable disease
Trial
Stage (AJCC 8th edition)
Treatment
Primary endpoint
KEYLYNK-012 (NCT04380636)
Stage IIIA–C
Pembrolizumab plus CRT followed by pembrolizumab with/without olaparib vs. CRT followed by durvalumab
PFS and OS
EA5181 (NCT04092283)
Stage III
Durvalumab plus CRT or CRT, followed by one year of durvalumab
OS
Skyscraper-03 (NCT04513925)
Stage III after CRT
Atezolizumab plus tiragolumab or durvalumab
PFS
Pacific-9 (NCT05221840)
Stage III after CRT
Durvalumab plus oleclumab or monalizumab or placebo
PFS
NCT04325763
Stage III after CRT
TQB2450 plus anlotinib or TQB2450 or placebo
PFS
Pacific-8 (NCT05211895)
PD-L1 positive stage III after CRT
Durvalumab plus either domvanalimab or placebo
PFS
NCT04585490
Stage III after CRT
MRD negative patients after CRT will receive consolidation durvalumab and MRD-positive patients will receive durvalumab plus four additional cycles of tremelimumab chemotherapy
MRD change as measured by ctDNA after tremelimumab chemotherapy
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