Table Info

Table 3.

Clinical characteristics according to KRAS and TP53 status

Variable	KRAS-wt; TP53-wt (n = 20)	KRAS-m; TP53-wt (n = 31)	KRAS-wt; TP53-m (n = 33)	KRAS-m; TP53-m (n = 23)
Age
Median (IQR)	71 (± 12)	68 (± 11)	63 (± 16)	61 (± 14)
Sex
Female	9 (45%)	8 (26%)	11 (33%)	9 (39%)
Male	11 (55%)	23 (74%)	22 (67%)	14 (61%)
Smoking status
Non-smoker	4 (20%)	2 (6%)	2 (6%)	1 (4%)
Smoker	15 (75%)	29 (94%)	31 (94%)	22 (96%)
Missing	1 (5.0%)	0 (0%)	0 (0%)	0 (0%)
Histology
Squamous	2 (10%)	0 (0%)	5 (15%)	1 (4%)
Non squamous	18 (90%)	31 (100%)	28 (85%)	22 (96%)
Line of treatment
1	6 (30%)	14 (45%)	7 (21%)	6 (26%)
> 1	14 (70%)	17 (55%)	26 (79%)	17 (74%)
PD-L1 TPS %
0	3 (15%)	5 (16%)	4 (12%)	2 (9%)
1–49	6 (30%)	6 (19%)	6 (18%)	5 (22%)
> 50	7 (35%)	15 (48%)	12 (36%)	10 (43%)
Missing	4 (20.0%)	5 (16.1%)	11 (33.3%)	6 (26.1%)
Number of mutation (s)
Median (IQR)	0 (± 1.0)	1.0 (± 0.50)	2.0 (± 1.0)	2.0 (± 0)
KRAS mutation
Other than G12C		22 (71%)		14 (61%)
G12C		9 (29%)		9 (39%)

KRAS: Kirsten rat sarcoma viral oncogene homolog; KRAS-wt: KRAS wild type; KRAS-m: KRAS mutated; TP53: tumor protein p53; TP53-wt: TP53 wild type; TP53-m: TP53 mutated; PD-L1: programmed death ligand 1; TPS: tumor proportion score; ICR: confidence interval range

Declarations

Author contributions

HDSB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. RE: Data curation, Writing—original draft, Writing—review & editing. ZM: Validation, Writing—review & editing. HB: Validation, Writing—review & editing, Supervision. RBD: Validation, Writing—review & editing. LG: Validation, Writing—review & editing. EF: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The present study has been accepted and registered to the relevant institutional research (OncoHEGP: PRB-HEGP-URC NIF) and ethical committee (European Georges Pompidou Hospital) and has been conducted in accordance with the Declaration of Helsinki. All patients provided informed consent under the European Georges Pompidou Hospital approved protocol allowing collection and analysis of data.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

Not applicable.

Copyright

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