Table Info

Table 4.

Median PFS according to KRAS and TP53

KRAS and TP53 molecular profile	N	Events	PFS median	0.95LCL	0.95UCL
KRAS-wt; TP53-wt	20	20	3.3	1.8	10.9
KRAS-m; TP53-wt	31	27	3.7	2.3	14.0
KRAS-wt; TP53-m	33	25	4.1	2.2	14.1
KRAS-m; TP53-m	23	21	3.0	1.9	17.2

KRAS: Kirsten rat sarcoma viral oncogene homolog; TP53: tumor protein p53; N: number of patients; KRAS-wt: KRAS wild type; KRAS-m: KRAS mutated; TP53-wt: TP53 wild type; TP53-m: TP53 mutated; PFS: progression free survival; LCL: lower control limit; UCL: upper control limit

Declarations

Author contributions

HDSB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. RE: Data curation, Writing—original draft, Writing—review & editing. ZM: Validation, Writing—review & editing. HB: Validation, Writing—review & editing, Supervision. RBD: Validation, Writing—review & editing. LG: Validation, Writing—review & editing. EF: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The present study has been accepted and registered to the relevant institutional research (OncoHEGP: PRB-HEGP-URC NIF) and ethical committee (European Georges Pompidou Hospital) and has been conducted in accordance with the Declaration of Helsinki. All patients provided informed consent under the European Georges Pompidou Hospital approved protocol allowing collection and analysis of data.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

Not applicable.

Copyright

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