Anticancer activity of different phytoconstituents

S. No.Active constituentsActivityAnimal modelMajor findingReferences
1.GinsenosidesAntitumorMCF-7 xenograft mouse modelFA-Rg5-BSA NPs had more efficacy in suppressing tumor development compared to Rg5 and Rg5-BSA NPs, demonstrating improved tumor accumulation capability.[57]
2.QC, miquelianin, isoquercetinAntitumor and antimetastatic efficacyOrthotopic-4T1 breast tumor modelQu-NPs enhanced the notable anticancer and antimetastatic activities by suppressing uPA.[58]
3.Tymol, carvacrol, linalool, p-cymeneAntitumorHomogenous matrix modelZMSLN exhibited much superior antitumor efficacy compared to ZMEO and ZMSLN had a clear inhibitory impact on cell proliferation.[60, 110]
4.Poly-d-glucosamineAntimetastatic and antitumorHepatocarcino-ma cells modelIncreased cell-killing power and improved ability to be absorbed by the body.[66, 111]
5.CurcuminAntitumor, brain tumors, breast and pancreatic cancersXenograft mouse modelFA-functionalized NPs with a magnetic field improved the cytotoxicity of drug-loaded nanocomposites.[74, 112]
6.CampthothecinAntitumorAlbumin-bound PTX model, tumor xenograftsA more easy administration and efficacy and safety data support nab-PTX as a breast cancer reference taxane.[84, 113]
7.PiperineAntitumor and prostate cancerNude mice model xenograftedBlack pepper has been identified as a powerful nutraceutical that may effectively inhibit the development of chronic myeloid leukemia.[89, 114, 115]

BSA: bovine serum albumin; FA: folic acid; NPs: nanoparticles; PTX: paclitaxel; QC: quercetin