Table Info

Table 4.

Association between telomere length and clinicopathological characteristics of breast cancer patients

Variable	Studies (n)	Patients (n)	Telomere length		OR (95% CI)	P-value	Heterogeneity		Model
Variable	Studies (n)	Patients (n)	Short	Long	OR (95% CI)	P-value	I² (%)	P	Model
Tumor grade (3 vs. 1–2)	2	683	165 vs. 297	78 vs. 143	1.29 (0.90–1.85)	0.17	0	0.86	Fixed
Tumor stage (III–IV vs. I–II)	3	905	32 vs. 603	21 vs. 249	1.18 (0.65–2.16)	0.58	0	0.89	Fixed
Menopausal status (premenopausal vs. postmenopausal)	2	1,516	314 vs. 614	170 vs. 418	1.34 (1.06–1.70)	0.01^*	20.84	0.26	Fixed
Lymph node metastasis (positive vs. negative)	2	389	101 vs. 102	95 vs. 91	1.45 (0.34–6.26)	0.62	83.33	0.01	Random
HER2 (positive vs. negative)	2	1,550	514 vs. 436	379 vs. 221	0.92 (0.73-1.15)	0.44	0	0.51	Fixed
ER (positive vs. negative)	3	1,522	736 vs. 198	431 vs. 157	1.12 (0.86–1.44)	0.40	0	0.75	Fixed
PR (positive vs. negative)	3	1,521	633 vs. 302	406 vs. 180	0.93 (0.73–1.19)	0.58	42.81	0.58	Fixed

^* Statistically significant. CI: confidence intervals; ER: estrogen receptor; HER2: human epidermal growth factor receptor 2; OR: odds ratio; PR: progesterone receptor

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/1002289_sup_1.pdf.

Declarations

Author contributions

DMAS and KGP: Conceptualization, Data curation, Writing—original draft, Writing—review & editing. TA, DSH, and SLA: Supervision, Validation. All authors provided feedback and approved the final version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Ethical approval was not required as this study involved the secondary analysis of published data without direct patient interaction.

Consent to participate

Consent to participate was not required as this study involved the secondary analysis of published data without direct patient interaction.

Consent to publication

Not applicable.

Availability of data and materials

All data generated or analyzed for this study are included in the manuscript and the supplementary files.

Funding

Not applicable.

Copyright

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