Table Info

Table 5.

Overview of studies included in the systematic review for genito-urinary primaries

Author, year	Study type	Primary	Patient	SRT	Systemic therapy	Non-target response	Criteria
Ishiyama et al. [65], 2012	Case report	RCC	61*, M	18 Gy SRS and 40 Gy/8 fx SBRT to spinal metastases	None	PR on all mtxs treated at 2 months FUP, and in non-target other spine metastases; brain PD	Response outside RT field limited by blood-brain barrier
Xie et al. [66], 2017	Case report	RCC	54*, M	32 Gy/4 fx to a paraortic N mass	Previous sunitinib, concomitant pembrolizumab	CR of all multiple mtxs 2.2 months after	Response outside RT field
Laplant et al. [67], 2017	Case report	RCC	24*, M	18–27 Gy/3 fx dose-painting SBRT on sacral mass	3 previous therapeutic lines. Concomitant dual checkpoint blockade (nivolumab and ipilimumab) started 2 weeks before RT, only nivolumab continued after and then stopped	After 1 month, PR on pelvic mass and PR of multiple lung and N mtxs. Progression-free 12 months after	Temporal
Dengina et al. [68], 2019	Prospective multicentic	RCC	1 out of 17 (6%)	50 Gy/5 fx lung SBRT	Previous pazopanib and sorafenib, then everolimus with SD for 2.5 years	PR in all visible mtxs in the lungs and mediastinum, up to 50%	Response outside RT field
Margulis et al. [69], 2021	Prospective monocentric	RCC	1 out of 6 (17%)	Neoadj lung SBRT	NR	CR to lung treated metastasis (SBRT plus surgery) and also to non-treated multiple other lung metastases, with no PD at 36 months FUP	No concomitant systemic treatment
Zhang et al. [70], 2021	Case report	RCC	40*, F	30 Gy/6 fx SBRT for retroperitoneal N 2nd course 30 Gy/5 fx SBRT for pelvic mass under PD	Previous sunitinib ×20, concomitant pembrolizumab plus axitinib	PR on all metastases 2 months after each SBRT. PD at 7 months FUP after the second SBRT for tumor PD and multiple organs failure	PD under IT
Feinaj et al. [71], 2024	Case report	RCC	65*, M	-	Multiple lines of CHT and IT. Concomitant pembrolizumab plus lenvatinib	CR at 2 months of multiple skin. Lung, N sites	Response outside RT field
Kono et al. [72], 2023	Case report	Bladder	60*, F	52 Gy/8 fx lung SBRT	Previous TURB twice, BCG twice, CHT gemcitabine and cicplatin ×2, neoadj and concomitant pembrolizumab	2 months after, CR of the BMs for which SRS was planned	Response outside RT field
Higa et al. [73], 2020	Retrospective monocentric	Prostate	0 out 10 (0%)	NR	Pembrolizumab	None	Response outside RT field

* Age at time of SRT. SRS: stereotactic radiosurgery; fx: fraction(s); SBRT: stereotactic body radiotherapy; PD: progression disease; NR: not reported; RT: radiation treatment; SD: stable disease; CHT: chemotherapy; IT: immunotherapy; PR: partial response; mtxs: metastases; FUP: follow-up; CR: complete response; RCC: renal cell carcinoma; F: female; M: male; N: node/nodal; SRT: stereotactic radiation techniques; TURB: trans urethral resection of bladder; BCG: Bacillus Calmette-Guerin; neoadj: neoadjuvant

Declarations

Author contributions

AB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. M Caroprese: Conceptualization, Investigation, Writing—original draft. CF: Conceptualization, Investigation, Writing—original draft. EC: Investigation, Writing—original draft. CAG: Investigation, Writing—review & editing. CO: Investigation, Writing—original draft. SC: Investigation, Writing—original draft. AF: Investigation, Writing—original draft, Writing—review & editing. M Conson: Validation, Writing—review & editing, Supervision. RP: Conceptualization, Investigation, Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Datasets are available on request.

Funding

Not applicable.

Copyright

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