Table Info

Table 6.

Overview of other studies included in the systematic review

Author, year	Study type	Primary	Patient	SRT	Systemic therapy	Non-target response	Criteria
Welsh et al. [74], 2019	Prospective monocentric	Various, mainly NSCLC	28/106 (26%)	50 Gy/4 fx or 60 Gy/10 fx to liver or lung mtxs	Ipilimumab	26% rates of clinical benefit of non-irradiated tumor volume	Response outside the RT field
Menon et al. [75], 2019	Prospective monocentric	Various	16/26 (62%)	Various	IT	PR/CR in 58% of low-dose lesions versus 18% of no-dose ones (P = 0.0001)	Response outside RT field
Tubin et al. [76], 2019	Retrospective monocentric	Various	22/60 (37%)	Various	None	43% AE, 20% BE	Response outside RT field
Woody et al. [77], 2022	Retrospective monocentric	Various, mainly NSCLC	0/125 (0%)	60 Gy/8 fx to primary	None	None	NR
Damen et al. [78], 2022	Retrospective monocentric	Various	2/11 (18%)	NR	IT	NR	Temporal
Zagardo et al. [79], 2024	Retrospective monocentric	Various	0/28 (0%)	30 Gy (18–50)/5 fx (1–5)	IT	None	Response outside RT field
Chang et al. [80], 2024	Prospective monocentric	Various	10/26 (39%)		Ipilimumab/Nivolumab	38.5% (50% in the nivolumab group)	Response outside RT field with SRT-IT > IT without SRT
Zafra et al. [81], 2024	Prospective multicentric	Various, mainly lung	5/14 (36%)	24–35 Gy/3–5 fx to mainly lung mtxs	IT	36% in cohort A (IT + SBRT)	Response outside RT field
Mizumatsu and Nomura [82], 2023	Case report	DLBCL	75*, M	21 Gy/3 fx to frontal bone	None	CR on orbital and temporal bone	Negligible dose, no concomitant systemic treatment
Feng et al. [83], 2022	Case report	Giant cell tumor of bone	37*, F	44 Gy/4 fx to 3 lung mtx	None	PR with 22.2% reduction of a 4th lung mtx	No concomitant systemic treatment
Callaghan et al. [84], 2020	Case series	Sarcoma	NR	24 Gy/3 fx on tumor bed recurrence	Neoadjuvant (2 cycles), concomitant, adjuvant pembrolizumab (tot 26)	PR on a bladder metastatic lesion 8 months after, with no PD after 20 months	Temporal

* Age at time of SRT. DLBCL: diffuse large B-cell lymphoma; NR: not reported; mtxs: metastases; mtx: metastasis; fx: fraction(s); IT: immunotherapy; PR: partial response; CR: complete response; AE: abscopal effect; BE: bystander effect; SBRT: stereotactic body radiotherapy; PD: progression disease; RT: radiation treatment; SRT: stereotactic radiation techniques; NSCLC: non-small cell lung cancer; F: female; M: male; tot: total

Declarations

Author contributions

AB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. M Caroprese: Conceptualization, Investigation, Writing—original draft. CF: Conceptualization, Investigation, Writing—original draft. EC: Investigation, Writing—original draft. CAG: Investigation, Writing—review & editing. CO: Investigation, Writing—original draft. SC: Investigation, Writing—original draft. AF: Investigation, Writing—original draft, Writing—review & editing. M Conson: Validation, Writing—review & editing, Supervision. RP: Conceptualization, Investigation, Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Datasets are available on request.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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