MKIs, HS-TKIs, and immunotherapy used as a single agent or in combination for the neoadjuvant treatment of patients with thyroid cancer inside the clinical trials that are still ongoing and/or actively recruiting participants

DrugTumorStudy typeRecruitment statusClinicalTrial.gov ID
LarotrectinibSolid tumor with documented NTRK gene fusion rearrangementPhase 2Active, not recruitingNCT02576431
LarotrectinibSolid tumor with documented NTRK gene fusion rearrangementPhase 2Active, not recruitingNCT02637687
LenvatinibDTC, PDTCPhase 2RecruitingNCT04321954
SelpercatinibDTC, PDTC, ATC, MTCPhase 2Active, not recruitingNCT04759911
AnlotinibDTC, PDTC, MTCPhase 2Unknown statusNCT04309136
Camrelizumab + ApatinibDTC, PDTC, MTCPhase 2Unknown statusNCT04612894
PembrolizumabDTC, PDTCPhase 2Not yet recruitingNCT05852223
Nivolumab + IpilimumabDTC, ATC, MTCPhase 2Active, not recruitingNCT03246958
Cabozantinib + Nivolumab + IpilimumabDTC, PDTCPhase 2Active, not recruitingNCT03914300

MKIs: multikinase inhibitors; HS-TKIs: highly selective tyrosine kinase inhibitors; NTRK: neurotrophic tyrosine receptor kinase; DTC: differentiated thyroid cancer; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer; MTC: medullary thyroid cancer