Table Info

Table 1.

Characteristics of colorectal cancers with APC, RNF43, CTNNB1, or TCF7L2 alterations from the Cancer Genome Atlas (TCGA)

Characteristic	Entire cohort (n = 594)	Quadruple altered (n = 95)	APC only altered (n = 300)	Triple altered (n = 44)	Quadruple wild type (n = 95)	P
Age (mean ± SD)	66.1 ± 13.4	64.4 ± 13	66.2 ± 11.9	65.8 ± 16.5	65.7 ± 14.3	0.72
Age
≤ 65 years-old	260 (43.9)	48 (51.1)	134 (44.8)	18 (40.9)	40 (42.1)	0.56
> 65 years-old	332 (56.1)	46 (48.9)	165 (55.2)	26 (59.1)	55 (57.9)	0.56
NA	2	1	1	0	0	-
Sex
Male	312 (52.7)	47 (50)	164 (54.8)	23 (52.3)	43 (45.3)	0.41
Female	280 (47.3)	47 (50)	135 (45.2)	21 (47.7)	52 (54.7)	0.41
NA	2	1	1	0	0	-
Stage
I	104 (17.9)	13 (14.4)	59 (20.1)	6 (13.6)	17 (18.3)	I–II versus III–IV: 0.26
II	220 (37.9)	39 (43.3)	98 (33.5)	23 (52.3)	41 (44.1)
III	170 (29.3)	23 (25.6)	97 (33.1)	12 (27.3)	19 (20.4)
IV	86 (14.8)	15 (16.7)	39 (13.3)	3 (6.8)	16 (17.2)
NA	14	5	7	0	2	-
Location primary
Colon	436 (74.1)	70 (75.3)	209 (70.4)	41 (93.2)	71 (75.5)	0.01
Rectal	152 (25.9)	23 (24.7)	88 (29.6)	3 (6.8)	23 (24.5)	0.01
NA	6	2	3	0	1	-

Percentages are shown in parentheses. NA: not available; SD: standard deviation; APC: adenomatous polyposis coli. -: no data

Declarations

Author contributions

IAV: Conceptualization, Investigation, Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares that there have no conflicts of interest.

Ethical approval

The study was an analysis of previously published data and was exempt from approval by an Ethics Committee.

Consent to participate

The study was an analysis of previously published data and informed consent was not required or obtained.

Consent to publication

Not applicable.

Availability of data and materials

The datasets analyzed for this study can be found in the Cancer Genome Atlas [http://www.cancer.gov/ccg/]; Cancer Cell Line Encyclopedia [http://www.sites.broadintitute.org/ccle/]; Genomics of Drug Sensitivity in Cancer (GDSC) project [http://www.cancerrxgene.org]; project Achilles, Drive, Marcotte DEMETER2 [http://www.depmap.org/portal/achilles]; DepMap, Public 24Q2+Score, and Chronos projects [http://www.depmap.org].

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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