Subtype, tumor mutation burden (TMB), aneuploidy score (AS), and fraction genome altered (FGA) in colorectal cancers with or without APC and other WNT/β-catenin pathway alterations from the Cancer Genome Atlas (TCGA)
Characteristic
Entire cohort (n = 594)
Quadruple altered (n = 95)
APC only altered (n = 300)
Triple altered (n = 44)
Quadruple wild type (n = 95)
P
Subtype
GS
58 (12.7)
11 (12.7)
39 (13.8)
2 (5)
6 (12)
GS versus CIN versus MSI: < 0.00001
CIN
328 (71.4)
46 (53.5)
235 (83)
14 (35)
33 (66)
MSI
63 (13.7)
19 (22.1)
9 (3.2)
24 (60)
11 (22)
POLE
10 (2.2)
10 (11.7)
0
0
0
-
NA
135
9
17
4
45
-
TMB
≤ 10 mutations/Mb
451 (84.5)
63 (66.3)
288 (96)
17 (38.6)
83 (87.4)
< 0.00001
> 10 mutations/Mb
83 (15.5)
32 (33.7)
12 (4)
27 (61.4)
12 (12.6)
NA
60
0
0
0
0
-
AS
< 4
108 (18.4)
30 (32.3)
39 (13.1)
29 (65.9)
15 (15.8)
< 0.00001
4–24
427 (72.9)
58 (62.4)
226 (76.1)
15 (34.1)
70 (73.7)
> 24
51 (8.7)
5 (5.3)
32 (10.8)
0
10 (10.5)
NA
8
2
3
0
0
-
FGA
< 0.075
115 (19.7)
28 (30.1)
32 (10.9)
24 (55.8)
16 (17)
< 0.00001
0.075–0.35
319 (54.7)
49 (52.7)
179 (61.1)
15 (34.9)
54 (57.5)
> 0.35
149 (25.6)
16 (17.2)
82 (28)
4 (9.3)
24 (25.5)
NA
11
2
7
1
1
-
Percentages are shown in parentheses. GS: genomically stable; CIN: chromosomal instability, MSI: microsatellite instability; NA: not available; POLE: polymerase epsilon. -: no data
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