Sensitivities (mean IC50, μM) of colorectal cancer cell lines with or without APC and other WNT/β-catenin pathway mutations to porcupine inhibitors, tankyrase inhibitors, and EGFR inhibitors
Groups
Porcupine inhibitors
TNKRS inhibitors
EGFR inhibitors
LGK974
IWP-2
Wnt-C59
AZ6102
MN-64
WIKI4
XAV939
Cetuximab
Erlotinib
Quadruple mutated (n = 6)
138.5 (77.9)
33.31 (16.56)
150.8 (136.6)
25.39 (38.13)
211.7 (84.2)
79.01 (64.09)
156.1 (76.8)
543.5 (367.2)
21.01 (33.74)
APC only mutated (n = 7)
130.04 (91.3)
38.72 (28.7)
168.02 (164.6)
29.79 (48.04)
218.3 (189.2)
45.13 (22.23)
175.2 (113.5)
418.6 (494.4)
30.67 (57.39)
Triple mutated (n = 7)
134.57 (94.1)
37.01 (32.9)
154.5 (122.2)
15.31 (10.66)
168.1 (135.8)
66.79 (52.63)
110.5 (40.7)
657.1 (349.4)
22.75 (16.56)
Quadruple wild type (n = 2)
64.05 (30.05)
31.6 (0.91)
135.5 (127.7)
4.2 (2.82)
110.5 (68.3)
NA
51.61 (62.8)
838.9 (322.4)
5.51 (4.32)
ANOVA
F = 0.4, P = 0.74
F = 0.06, P = 0.97
F = 0.03, P = 0.99
F = 0.38, P = 0.76
F = 0.4, P = 0.75
F = 0.82, P = 0.45
F = 1.5, P = 0.22
F = 0.69, P = 0.56
F = 0.23, P = 0.87
Standard deviations (SD) are shown in parentheses. Data are from the Genomics of Drug Sensitivity in Cancer (GDSC) project. NA: not available; APC: adenomatous polyposis coli
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