Table Info

Table 1.

Outcomes in randomized clinical trials of metastatic pancreatic cancer (first-line treatment)

Chemotherapy	Phase	Number of patients	mOS	mPFS	ORR	Ref.
Gemcitabine vs. 5-fluorouracile	II/III	126	5.56 months vs. 4.41 months (P = 0.0025)	2.33 months vs. 0.92 months (P = 0.0002)	5.4% vs. 0% (nc)	[5]
Gemcitabine plus erlotinib vs. gemcitabine	III	569	6.24 months vs. 5.91 months (P = 0.038, HR: 0.82)	3.75 months vs. 3.55 months (P = 0.004, HR: 0.77)	8.6% vs. 8% (nc)	[6]
FOLFIRINOX vs. gemcitabine	II/III	342	11.1 months vs. 6.8 months (P < 0.001, HR: 0.57)	6.4 months vs. 3.3 months (P < 0.001, HR: 0.47)	31.6% vs. 9.4% (P < 0.001)	[7]
Gemcitabine plus nab-paclitaxel vs. gemcitabine	III	861	8.5 months vs. 6.7 months (P < 0.001, HR: 0.72)	5.5 months vs. 3.7 months (P < 0.001, HR: 0.69)	23% vs. 7% (P < 0.001)	[8]
Gemcitabine plus capecitabine vs. gemcitabine	III	533	7.1 months vs. 6.2 months (P = 0.08, HR: 0.86)	5.3 months vs. 3.8 months (P = 0.004, HR: 0.78)	19.1% vs. 12.4% (P = 0.034)	[9]
NALIRIFOX vs. gemcitabine plus nab-paclitaxel	III	770	11.1 months vs. 9.2 months (P = 0.036, HR: 0.83)	7.4 months vs. 5.6 months (P < 0.0001, HR: 0.69)	42% vs. 36% (P = 0.11)	[10]

mOS: median overall survival; mPFS: median progression-free survival; ORR: objective response rate; Ref.: references; nc: not calculated; HR: hazard ratio

Declarations

Author contributions

VC: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Visualization. MRDA: Conceptualization, Investigation, Writing—review & editing, Validation, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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