Ongoing trials investigating ICIs in MPM (Source: Clinicaltrials.gov)
Combination
Treatment
Identifier/reference
Phase
Setting/line of treatment
Status
Estimated enrollment
Notes
Vaccine
Nivolumab plus galinpepimut-S
NCT04040231
I
Reccurent/relapsed
Recruiting
10
Open label, single group assignment
Single agent
Nivolumab
NCT03063450 (CONFIRM)
III
Relapsed
Active, not recruiting
336
Double-blind, placebo controlled
ICI
Nivolumab plus ipilimumab
NCT02899299 (CheckMate-743)
III
First Line
Active, not recruiting
606
Open label, randomized
Nivolumab/nivolumab plus ipilimumab
NCT02716272 (MAPS2)
II
Relapsed
Active, not recruiting
125
Open label, randomized
Chemotherapy
Durvalumab plus chemotherapy
NCT02899195 (PrE0505)
II
First line
Active, not recruiting
55
Open label, non-randomized
Pembrolizumab/pembrolizumab plus chemotherapy
NCT02784171
II/III
First line
Active, not recruiting
520
Open label, randomized
Nivolumab plus chemotherapy
NCT04177953
II
Adjuvant
Recruiting
92
Open label, randomized
Atezolizumab plus gemcitabine
NCT04480372
II
Relapsed
Not yet recruiting
67
Open label, single group assignment
Atezolizumab plus cisplatin and pemetrexed
NCT03228537
I
Neoadjuvant
Active, not recruiting
28
Open label, single group assignment
Radiotherapy
Pembrolizumab after radiation therapy
NCT02959463
I
Maintenance
Recruiting
24
Open label, non-randomized
Anti-angiogenic
Atezolizumab plus bevacizumab and chemotherapy
NCT03762018 (BEAT-meso)
III
First line
Recruiting
320
Open label, randomized
Photodynamic therapy
Nivolumab after intrapleural photodynamic therapy
NCT04400539
II
Maintenance
Not yet recruiting
20
Open label, single group assignment, pilot study
Declarations
Author contributions
LC, FP, FM, AL, EL, FP wrote the manuscript and generated the figure and table. JA and RB contributed to the revisions of the manuscript. All authors approved the manuscript for publication.
Conflicts of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Relevant financial activities outside the submitted work: JA reports receiving commercial research grants from Amphera and Roche, holds ownership interest (including patents) in Amphera BV, and is a consultant/advisory board member for Amphera, Boehringer Ingelheim, Bristol-Myers Squibb, Eli-Lilly, MSD, Takeda, Bayer, Astra Zeneca and Roche. RB is a consultant/advisory board member for Astra Zeneca, Boehringer Ingelheim, Novartis, MSD, Otsuka, Eli-Lilly, Roche. The other authors have no conflicts of interest to declare.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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