Table Info

Table 2.

Active trials of ADCs in SCLC

Agent	Phase	Status	Trial identifier	Indications	Sponsor
FZ-AD005	I	Recruiting	NCT06424665	Advanced solid tumors	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co.
Sacituzumab govitecan	I/II	Recruiting	NCT04826341	SCLC, extra-pulmonary small cell neuroendocrine cancer & homologous recombination-deficient cancers resistant to PARP inhibitors	National Cancer Institute
Sacituzumab govitecan	II	Active, not recruiting	NCT03964727	Advanced solid tumors	Gilead Sciences
Sacituzumab govitecan	II	Not yet recruiting	NCT06667167	ES-SCLC	Nir Peled
Sacituzumab tirumotecan	I/II	Recruiting	NCT04152499	Advanced solid tumors	Klus Pharma Inc.
Datopotamab deruxtecan	I	Recruiting	NCT03401385	Advanced solid tumors	Daiichi Sankyo
Ifinatamab deruxtecan	I/II	Recruiting	NCT04145622	Advanced solid tumors	Daiichi Sankyo
Ifinatamab deruxtecan	Ib/II	Recruiting	NCT06362252	ES-SCLC	Daiichi Sankyo
Ifinatamab deruxtecan	II	Active, not recruiting	NCT05280470	ES-SCLC	Daiichi Sankyo
Ifinatamab deruxtecan	III	Recruiting	NCT06203210	Relapsed SCLC	Daiichi Sankyo
HS-20093	I	Recruiting	NCT05276609	Advanced solid tumors	Hansoh BioMedical R&D Company
HS-20093	III	Recruiting	NCT06498479	Relapsed SCLC	Hansoh BioMedical R&D Company
HS-20093	III	Not yet recruiting	NCT06526624	Limited-stage SCLC	Hansoh BioMedical R&D Company
ABBV-706	I	Recruiting	NCT05599984	Advanced solid tumors	AbbVie
BL-B01D1	Ia	Recruiting	NCT05194982	Locally advanced or metastatic solid tumor	Sichuan Baili Pharmaceutical Co., Ltd.
BL-B01D1	II	Recruiting	NCT05924841	ES-SCLC	Sichuan Baili Pharmaceutical Co., Ltd.
BL-B01D1	II	Recruiting	NCT06437509	ES-SCLC	Sichuan Baili Pharmaceutical Co., Ltd.
BL-B01D1	III	Recruiting	NCT06500026	Relapsed SCLC	Sichuan Baili Pharmaceutical Co., Ltd.
BL-B01D1	I/IIa	Recruiting	NCT06618287	Advanced solid tumors	Bristol-Myers Squibb
Tusamitamab ravtansine	I	Active, not recruiting	NCT02187848	Advanced solid tumors	Sanofi

ADCs: antibody drug conjugates; SCLC: small cell lung cancer; ES-SCLC: extensive-stage SCLC

Declarations

Author contributions

EIB, JC, and LF: Conceptualization, Data curation, Investigation, Project administration, Writing—original draft, Writing—review & editing. DP: Conceptualization, Investigation, Visualization, Project administration, Supervision, Writing—review & editing. SA: Conceptualization, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing. RH: Conceptualization, Resources, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing.

Conflicts of interest

RH is a consultant for Targeted Oncology, EMD Serono, and Takeda, received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group, participated in an advisory board meeting for Oncohost, and receives institutional funding from Bristol Myers Squibb Foundation. All other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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