Table Info

Table 3.

Terminated and withdrawn trials of ADCs

Agent	Trial identifier	Status	Reason for termination/withdrawal
Rovalpituzumab tesirine	NCT02709889	Terminated	Strategic considerations
Rovalpituzumab tesirine	NCT02819999	Terminated	Strategic considerations
Rovalpituzumab tesirine	NCT03026166	Terminated	Enrollment was stopped after the dose-limiting toxicity (DLT) evaluation phase of cohort 2
Rovalpituzumab tesirine	NCT03033511	Terminated	Independent Data Monitoring Committee recommendation
Rovalpituzumab tesirine	NCT03334487	Withdrawn	Strategic considerations
HS-20093	NCT06052423	Withdrawn	Research and development strategy adjustment
Tusamitamab ravtansine	NCT02187848	Terminated	Sponsor decision

ADCs: antibody drug conjugates

Declarations

Author contributions

EIB, JC, and LF: Conceptualization, Data curation, Investigation, Project administration, Writing—original draft, Writing—review & editing. DP: Conceptualization, Investigation, Visualization, Project administration, Supervision, Writing—review & editing. SA: Conceptualization, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing. RH: Conceptualization, Resources, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing.

Conflicts of interest

RH is a consultant for Targeted Oncology, EMD Serono, and Takeda, received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group, participated in an advisory board meeting for Oncohost, and receives institutional funding from Bristol Myers Squibb Foundation. All other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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