Table Info

Table 4.

Key trials of BiTEs in SCLC

Agent	Tumor target/T cell target	Trial identifier	Phase	ORR	OS	PFS	Grade 3 or > TRAEs
Tarlatamab	DLL3/CD3	DeLLphi-300 (NCT03319940)	I	23.4% (95% CI: 15.7–32.5)	13.2 months (95% CI: 10.5–not reached)	3.7 months (95% CI: 2.1–5.4)
Tarlatamab	DLL3/CD3	DeLLphi-301 (NCT05060016)	II	40% (97.5% CI: 29–52) 10 mg, 32% (97.5% CI: 21–44) 100 mg		4.9 months (95% CI: 2.9–6.7) 10 mg, 3.9 months (95% CI: 2.6–4.4) 100 mg	26% 10 mg, 33% 100 mg

BiTEs: bispecific T-cell engagers; SCLC: small cell lung cancer; DLL3: delta-like ligand 3; CI: confidence interval; ORR: objective response rate; OS: overall survival; PFS: progression-free survival; TRAEs: treatment-related adverse events

Declarations

Author contributions

EIB, JC, and LF: Conceptualization, Data curation, Investigation, Project administration, Writing—original draft, Writing—review & editing. DP: Conceptualization, Investigation, Visualization, Project administration, Supervision, Writing—review & editing. SA: Conceptualization, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing. RH: Conceptualization, Resources, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing.

Conflicts of interest

RH is a consultant for Targeted Oncology, EMD Serono, and Takeda, received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group, participated in an advisory board meeting for Oncohost, and receives institutional funding from Bristol Myers Squibb Foundation. All other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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