Table Info

Table 5.

Trials of CAR-T cell therapies in SCLC

Cell type	Agent	Phase	Status	Trial identifier	Indications	Sponsor
NK cells	Anti-DLL3 NK cells	I	Recruiting	NCT05507593	R/R ES-SCLC	Tianjin Medical University
T cells	Anti-DLL3 CAR-T cells	I	Recruiting	NCT05680922	R/R ES-SCLC, LCNEC	Legend Biotech
T cells	Anti-DLL3 CAR-T cells (SNC115)	I	Recruiting	NCT06384482	R/R ES-SCLC, LCNEC	Shanghai Simnova Biotech
T cells	Anti-DLL3 CAR-T cells (AMG 119)	I	Suspended	NCT03392064	R/R ES-SCLC	Amgen
T cells	Anti-GD2 and iC9 CAR-T cells (iC9.GD2.CAR.IL-15 T cells)	I	Recruiting	NCT05620342	R/R ES-SCLC, stage IV NSCLC	UNC Lineberger
T cells	Anti-PD-L1/4-1BB DLL3 CAR-T cells (BHP01)	I	Not yet recruiting	NCT06348797	R/R ES-SCLC	Sichuan University

CAR: chimeric antigen receptor; SCLC: small cell lung cancer; DLL3: delta-like ligand 3; GD2: gangliosides disialoganglioside GD2; PD-L1: programmed death-ligand 1; ES-SCLC: extensive-stage SCLC; NSCLC: non-SCLC

Declarations

Author contributions

EIB, JC, and LF: Conceptualization, Data curation, Investigation, Project administration, Writing—original draft, Writing—review & editing. DP: Conceptualization, Investigation, Visualization, Project administration, Supervision, Writing—review & editing. SA: Conceptualization, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing. RH: Conceptualization, Resources, Investigation, Project administration, Supervision, Writing—original draft, Writing—review & editing.

Conflicts of interest

RH is a consultant for Targeted Oncology, EMD Serono, and Takeda, received honoraria from DAVA Oncology, Targeted Oncology, and The Dedham Group, participated in an advisory board meeting for Oncohost, and receives institutional funding from Bristol Myers Squibb Foundation. All other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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