Datasets from MM patients used in genomics studies presented in this review
Dataset
Technique
Number of patients
GEO series accession number
HOVON-65/GMMG-HD4
Affymetrix HG U133 plus 2.0 platform
320
GSE19784
UAMS-TT2UAMS-TT3
Affymetrix HG U133 plus 2.0 platform
340214
GSE24080
MRC-IX
Affymetrix HG U133 plus 2.0 platformGene Chip Mapping 500K Array setGenome variation profiling by SNP arraySNP genotyping by SNP array
258114
GSE15695
APEX/SUMMIT/CREST
Affymetrix U133 A/B platform
669
GSE9782
IFM-G
Affymetrix HG U133 plus 2.0 platform
182
GSE7039
Mayo Clinic cohort
Affymetrix U133A platform
162
GSE6477
CoMMpass
WES: Illumina TruSeq Exome EnrichmentWES: Agilent SureSelect Human All Exon + untranslated regions (UTRs) LibraryRNA-Seq: Illumina truSeq Stranded mRNA
1,150
dbGaP phs000748.v7.p4
HM
Affymetrix HG U133 plus 2.0 platform
206
Array Express public database (E-MTAB-372)
GIMEMAMMY-3006
118
GSE68871
GEO: Gene Expression Omnibus; HOVON65/GMMG-HD4: Dutch-Belgium Hemato-Oncology Group and German-speaking Myeloma Multicenter Group; UAMS-TT2/UAMS-TT3: University of Arkansas for Medical Sciences-Total Therapy 2/3; MRC-IX: Medical Research Council-IX; APEX: Assessment of Proteasome Inhibition for Extending Remissions; IFM-G: Intergroupe Francophone du Myelome; CoMMpass: the Relating Clinical Outcomes in MM to Personal Assessment of Genetic Profile Study; HM: Heidelberg-Montpellier; UTRs: untranslated regions
Declarations
Author contributions
SO performed data analyses and the writing of the paper. JM supervised the writing of the paper.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This work was supported by grants from INCa (Institut National du Cancer) PLBIO18-362 PIT-MM and PLBIO19-098 INCA_13832FATidique, ANR (the French National Research Agency) under the “Investissements d’avenir” program with the reference ANR-16-IDEX-0006, ANR (TIE-Skip; 2017-CE15-0024-01), ANR-18-CE15-0010-01 PLASMADIFF-3D, SIRIC Montpellier Cancer (INCa_Inserm_DGOS_12553), Labex EpiGenMed and Institut Universitaire de France. The funders had no role in analysis, decision to publish, or preparation of the manuscript.
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