Table Info

Table 1.

Parameter description and their baseline values with references

Parameters	Definition	Value	Reference
α	Net calcium influx rate through plasma membrane	0.04 μM/s	[38]
β	Maximum SOCE influx rate	0.520 μM/s	estimated
γ	Maximum influx of Ca²⁺ through TRPC1 channel	0.0001/s	estimated
δ	[Ca²⁺]_ER leaking rate	0.0014/s	estimated
ξ	Ca²⁺ export through NCX	7/s	estimated
p₁	Maximal flux through IP₃R2 channel	0.01747 μM/s	estimated
q₁	IP₃R₂ channel’s half-saturation constant	0.0518 μM	estimated
p₂	Maximal flux through SERCA1 channel	3.6926 μM/s	estimated
q₂	SERCA1 channel’s half-saturation constant	0.1 μM	[39]
p₃	Maximal flux through PMCA2 channel	7.34 μM/s	[34]
q₃	PMCA2 channel’s half-saturation constant	1.5 μM	[34]
c_es	Calcium concentration in extracellular space	1000.1812 μM	[40]
k_s	STIM1 ER Ca²⁺ affinity	50 μM	[34]
τ_s	SOCE timescale	30.1752 s	[34]

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100242_sup_1.pdf.

Declarations

Author contributions

GA, SG, and SC conceived and designed the study. SG performed the mathematical analysis. GA performed the numerical simulation. GA and SC interpreted the results. GA, SG, and SC contributed to the writing of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The work is supported by SERB (Govt. of India), grant no.: CRG/2019/005477. The work of GA is supported by THSTI PhD fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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