Table Info

Table 5.

Parametric recalibration table: the table describes the possible mechanisms to restore CRD under different parametric conditions. Here Doxo 1, Doxo 2, Doxo 3 denotes the categories when the baseline parameter set is increased by 25%, 50%, 75% respectively

Category	Parametric variation	Possible mechanism of restoration
Doxo 1	Single paramer variation	1. Decrease calcium influx rate through TRPC1 channel (γ)
		2. Increase SOCE timescale (τ_s)
		3. Decrease net calcium influx rate through plasma membrane (α)
		4. Decrease extracellular calcium concentration (c_es)
Doxo 2	Single parameter variation	1. Decrease TRPC1 calcium influx rate (γ)
Doxo 2	Single parameter variation	2. Decrease extracellular calcium concentration (c_es)
Doxo 3	Double parameter variation	1. Decrease SOCE flux rate (β) by 20% & decrease TRPC1 calcium influx rate (γ)
		2. Decrease SOCE flux rate (β) by 20% & increase SOCE timescale (τ_s)
		3. Decrease SOCE flux rate (β) by 20% & decrease SERCA1 channel’s half-saturation constant (q₂)
		4. Decrease SOCE flux rate (β) by 20% & decrease extracellular calcium concentration (c_es)

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100242_sup_1.pdf.

Declarations

Author contributions

GA, SG, and SC conceived and designed the study. SG performed the mathematical analysis. GA performed the numerical simulation. GA and SC interpreted the results. GA, SG, and SC contributed to the writing of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The work is supported by SERB (Govt. of India), grant no.: CRG/2019/005477. The work of GA is supported by THSTI PhD fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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