Table Info

Table 4.

Main human vimentin phosphorylation sites

Gene	Site	Putative kinase	Discovered by/inhibitor	Effect	Reference
VIM	Ser5/7/8/9/10	PKCα	Calyculin A (phosphatase)	Cell polarity	[63]
	Ser26/51/66	PAK1	Biochemical assays, selumetinib, vemurafenib	Abnormal assembly	[113, 114]
	Ser39	AKT/PKB	A-674563	Proteolytic protection, slowed polymerization?	[69]
	Ser56	AKT/PKB ROCK	A-674563 siRNA	Filament disassembly	[69] [72]
	Ser72	ROCK1	Targeted mutation, Y27632	Increased cell migration	[75, 76, 115]
	Ser73	AURKB	Biochemical assays	Mitosis?	[114, 116]
	Ser83	PLK-1, CaMKII	Biochemical assays, KN-93 (CaMKII inhibitor)	Filament disassembly and pathogen interaction	[77, 117, 118]

CaMKII: calmodulin-dependent protein kinase II

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100247_sup_1.pdf.

Declarations

Author contributions

CLG: writing and revision; MGR: writing; MVM: conceptualization, writing, revision and securing funding.

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Data are publicly available and reproduced from public and private, but fully and freely searchable, databases.

Funding

This work was funded by the Spanish Ministry of Science and Innovation (SAF2017-87408), AECC Seed award (2018-IDEAS18018VICE) and ECRIN-M3 from AECC/AIRC/CRUK. IBMCC is supported by the Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Ministry of Education of the Castilla-León Government (CLC-2017-01). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Copyright

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