Table Info

Table 3.

Active trials, both recruiting and not recruiting, testing the HER2 pathway

NCT	Phase	Status	Tumors	Line of treatment	Target	Experimental treatment	Standard treatment	Primary endpoints	Sponsor
NCT03613168	2	Completed	CCA	1 L	HER2	Cis + Gem + trastuzumab	N.A.	ORR, AEs	No-profit
NCT04430738	1/2	Recruiting	CCA	≥ 1 L (not prior oxaliplatin)	HER2	FOLFOX or CAPOX + tucatinib + trastuzumab	N.A.	AEs	Profit
NCT03602079	1/2	Recruiting	CCA	NTA	HER2	A166 (ADC targeting HER2)	N.A.	MTD, ORR	Profit
NCT00004074	1	Completed	eCCA and GBC	NTA	HER2	IL12 + trastuzumab	N.A.	MTD	No-profit
NCT04660929	1	Recruiting	CCA	NTA	HER2	CT-0508 (anti-HER2 CAR macrophages)	N.A.	Safety, tolerability and feasibility	Profit
NCT04466891	2	Recruiting	CCA	≥ 2 L	HER2	Zanidatamab	N.A.	ORR	Profit
NCT04579380	2	Recruiting	CCA	≥ 2 L	HER2	Tucatinib + trastuzumab	N.A.	ORR	Profit
NCT03821233	1	Recruiting	CCA	NTA	HER2	ZW49	N.A.	AEs, safety	Profit
NCT00005842	1	Completed	CCA	≥ 1 L		Trastuzumab + tipirfanib	N.A.	MTD, antitumor activity	No-profit

We also reported three trials defined as “completed” on www.clinicaltrials.gov, whose results have never been published. CAPOX: capecitabine + oxaliplatin; CAR: chimeric antigen receptor; ADC: antibody-drug conjugate

Declarations

Author contributions

MDM, DM, ES contributed conception and design of the review; AC, TG, FDV organized the database; GA, CP, CZ wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Massimo Di Maio received honoraria and had roles as consultant or advisor for AstraZeneca, Pfizer, Novartis, Roche, Takeda, Eisai, Janssen, Astellas; received institutional research grant by Tesaro e GlaxoSmithKline, outside the submitted work. All remaining authors declared no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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