Temperature fit parameters of the ADCs

ADCsTm
Peak-1
Tm
Peak-2
Tm
Peak-3
Tm
Peak-4
Trastuzumab64.8°C79.1°C
T-DM162.5°C74.8°C78.9°C
Trastuzumab-MCC-maytansinoid (DAR = 4.1)63.8°C73.0°C78.0°C
Trastuzumab-MC-VC-PAB-MMAE (DAR = 2.0)63.5°C75.1°C79.2°C
Trastuzumab-MC-VC-PAB-MMAE (DAR = 4.0)54.6°C62.0°C73.4°C78.0°C