Table Info

Table 2.

Main ongoing clinical trials of ADCs in ovarian cancer

Target	ADC	Trial	Phase	Setting	Treatment	Primary endpoint
FRα	Mirvetuximab soravtansine	MIROVA (NCT0427442)	II	Platinum-eligible FRα positive	Mirvetuximab soravtansine + carboplatin vs. platinum-based chemotherapy	PFS
		MIRASOL (NCT04209855)	III	Platinum-resistant FRα positive high	Mirvetuximab soravtansine vs. chemotherapy of investigator’s choice	PFS
		SORAYA (NCT04296890)	III	Platinum-resistant FRα positive high	Mirvetuximab soravtansine	ORR
		NCT03552471	I	Platinum-resistant and BRCA mutated platinum-sensitive FRα positive	Mirvetuximab soravtansine + rucaparib	RP2D
		NCT02996825	I	Platinum-resistant FRα positive	Mirvetuximab soravtansine +gemcitabine	RP2D
		NCT04606914	II	Neoadjuvant, newly diagnosed FRα positive high	Carboplatin + mirvetuximab soravtansine	PFS
Mesothelin	Anetumab ravtansine	NCT02751918	Ib	Platinum-resistant	Anetumab ravtansine + PLD	MTD
Mesothelin	Anetumab ravtansine	NCT03587311	II	Platinum-resistant	Bevacizumab + anetumab ravtansine or paclitaxel	PFS
TF	Tisotumab vedotin	InnovaTV 208 (NCT03657043)	II	Platinum-resistant	Tisotumab vedotin	ORR

BRCA: breast cancer gene

Declarations

Author contributions

MN and IC contributed to the conception and design of the manuscript. MN and IC wrote the first draft of the manuscript. MN, MDG, CS, and IC contributed to literature analysis. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

Ilaria Colombo: travel grants from Tesaro; technical support from: AstraZeneca (AZ), GlaxoSmithKline (GSK), Novartis, Merck Sharpe and Dohme (MSD); institutional grants for clinical trials (PI) from MSD, Bayer, Oasmia. None of the other authors have a conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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