Table Info

Table 3.

Main clinical trials of ADCs in endometrial and cervical cancer

Target	ADC	Trial	Phase	Setting	Treatment	Primary endpoint	Results
HER2	T-DM1	NCT02675829 [83]	II	HER2 pos tumors including endometrial cancer	T-DM1	ORR	ORR: 22%
HER2	T-DM1	NCT02465060 [84]	II	HER2 pos including endometrial and ovarian cancer	T-DM1	ORR	ORR: 9%
FRα	Mirvetuximab soravtansine	NCT01609556 [60]	I	FRα pos tumors including metastatic endometrial cancer	Mirvetuximab soravtansine	MTD/RP2D	ORR: 0%
Trop2	Sacituzumab govitecan	IMMU-132-01 (NCT01631552) [85]	I/II	Advanced epithelial cancer including endometrial, cervical and ovarian cancer	Sacituzumab govitecan	Safety (phase I) ORR (phase II)	ORR: 22.2%
TF	Tisotumab vedotin	InnovaTV 204 (NCT03438396) [86]	II	Previously treated recurrent or metastatic cervical cancer	Tisotumab vedotin	ORR	ORR: 24% PFS: 4.2 months
		InnovaTV 205 (NCT03786081) [87]	I/II	Recurrent or metastatic cervical cancer, first line	Tisotumab vedotin + carboplatin	DLT (phase I) ORR (phase II)	ORR: 55% PFS: 9.5 months
		InnovaTV 205 (NCT03786081) [87]	I/II	Recurrent or metastatic cervical cancer, second or third line	Tisotumab vedotin + pembrolizumab	DLT (phase I) ORR (phase II)	ORR: 38% PFS: 5.6 months

Declarations

Author contributions

MN and IC contributed to the conception and design of the manuscript. MN and IC wrote the first draft of the manuscript. MN, MDG, CS, and IC contributed to literature analysis. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

Ilaria Colombo: travel grants from Tesaro; technical support from: AstraZeneca (AZ), GlaxoSmithKline (GSK), Novartis, Merck Sharpe and Dohme (MSD); institutional grants for clinical trials (PI) from MSD, Bayer, Oasmia. None of the other authors have a conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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