Table Info

Table 4.

Main ongoing clinical trials of ADCs in endometrial and cervical cancer

Target	ADC	Trial	Phase	Setting	Treatment	Primary endpoint
HER2	Trastuzumab duocarmazine (SYD985)	NCT04205630	II	HER2 pos metastatic endometrial cancer	Trastuzumab duocarmazine	ORR
HER2	T-DXd	NCT04482309	II	HER2 pos tumors including ovarian, endometrial, and cervical cancer	T-DXd	ORR
FRα	Mirvetuximab soravtansine	NCT03832361	II	FRα pos persistent or recurrent endometrial cancer	Mirvetuximab soravtansine	ORR
FRα	Mirvetuximab soravtansine	NCT03835819	II	FRα pos advanced or recurrent serous endometrial cancer	Mirvetuximab soravtansine + pembrolizumab	ORR/PFS
Trop2	Sacituzumab govitecan	NCT04251416	II	Trop2 pos persistent or recurrent endometrial cancer	Sacituzumab govitecan	ORR
TF	Tisotumab vedotin	InnovaTV 301 (NCT04697628)	III	Previously treated recurrent or metastatic cervical cancer	Tisotumab vedotin vs. chemotherapy	OS

Declarations

Author contributions

MN and IC contributed to the conception and design of the manuscript. MN and IC wrote the first draft of the manuscript. MN, MDG, CS, and IC contributed to literature analysis. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

Ilaria Colombo: travel grants from Tesaro; technical support from: AstraZeneca (AZ), GlaxoSmithKline (GSK), Novartis, Merck Sharpe and Dohme (MSD); institutional grants for clinical trials (PI) from MSD, Bayer, Oasmia. None of the other authors have a conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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