Table Info

Table 3.

VEGF and EGFR TKIs in EGFR mutated NSCLC patients

Author	Phase	Line of Treatment	Patients	Treatment	Response rate (%)	Progression-free survival (months)	Overall survival (months)
Seto et al. JO25567 trial [34, 35]	II	First	154	Erlotinib + bevacizumab vs. erlotinib	69 vs. 64, P = 0.49	16 vs. 9.7, HR: 0.54; 95% CI: 0.36-0.79 P = 0.0015	47 vs. 47.4, HR: 0.81; 95% CI: 0.53-1.23 P = 0.3267
Saito et al. NEJ026 trial [36]	III	First	228	Erlotinib + bevacizumab vs. erlotinib	72 vs. 66, P = 0.31	16.9 vs.13.3, HR: 0.605; 95% CI: 0.417-0877; P = 0.016.	n.r.
Rosell et al. BELIEF [37]	II	First	109	Erlotinib + bevacizumab	77	13.2 (95% CI: 10.3-15.5)	28.2 (95% CI: 21.4-41.8)
Stinchcombe et al. [38]	II	First	88	Erlotinib + bevacizumab vs. erlotinib	81 vs. 83, P = 0.81	17.9 vs.13.5, HR: 0.81; 95% CI: 0.50-1.31; P =0.39	32.4 vs. 50.6, HR: 1.41; 95% CI: 0.71-2.81; P = 0.33
Ichihara et al. Okoyama trial [39]	II	First	42	Gefitinib + bevacizumab	73.8 (95% CI: 58.0-86.1)	14.4 (95% CI:10.1-19.2)	n.r.
Kitigawa et al. [40]	II	First	16	Gefitinib-bevacizumab vs. gefitinib	44 vs. 50	5.4 (80% CI: 5.0-13.9) vs. 15.1 (80% CI: 6.2-23.5)	1-year OS: 0.667 (95% CI: 0.195-0.904) vs. 0.75 (95% CI: 0.315-0.931)
Hata et al. ABC trial [41]	II	Any line	32	Afatinib + bevacizumab	18.8 (95% CI: 7.2-36.4)	6.3 (95% CI: 3.9-8.7)	n.r.
Nakagawa et al. RELAY trial [42]	III	First line	449	Erlotinib + Ramucirumab vs. Erlotinib	76 vs. 75, P = 0.741	19.4 vs. 12.4 HR: 0.59; 95% CI: 0.46-0.76, P < 0.0001	n.r.

Declarations

Author contributions

GP and AM conceived the paper and prepared the majority of the first draft, while the other authors contributed further sections. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

AM declares the following speakers’ bureau: Roche, Takeda, Pfizer, Boehringer Ingelheim, AstraZeneca, MSD Oncology, BMS. The other authors declare that no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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