Table Info

Table 3.

Currently recruiting and recently completed trials exploring the combination of ADC and IO agents

Phase	Trial	Organ system	ADC	Antibody target	Payload (class)	IO agent (mechanism of action)	Status
I	NCT03523572	Breast and urothelial	T-DXd	HER2	DXd (DDA)	Nivo (ICI)	Recruiting (2018)
I	NCT04042701	NSCLC, breast	T-DXd	HER2	DXd (DDA)	Pembrolizumab (ICI)	Recruiting (2020)
I	NCT03364348	Breast	T-DM1	HER2	DM1 (TI)	Utomilumab (CSA)	Recruiting (2017)
I	NCT03032107	Breast	T-DM1	HER2	DM1 (TI)	Pembrolizumab (ICI)	Recruiting (2017)
II	NCT02924883	Breast	T-DM1	HER2	DM1 (TI)	Atezolizumab (ICI)	Published 2021-negative trial
I	NCT02341625	Solid organ, mesothelioma	BMS-986148	Mesothelin	Unknown	Nivo (ICI)	Active (2015). Not recruiting
I	NCT03816358	Pancreatic	Anetumab ravtansine	Mesothelin	DM4 (TI)	Nivo + ipilimumab/Nivo + chemo (ICI)	Recruiting (2019)
I	NCT03455556	NSCLC	Anetumab ravtansine	Mesothelin	DM4 (TI)	Atezolizumab (ICI)	Completed (2018–2020)
I	NCT03126630	Mesothelioma	Anetumab ravtansine	Mesothelin	DM4 (TI)	Pembrolizumab	Recruiting (2017)
I	NCT04448886	HR⁺/HER2-breast	SG	Trop-2	SN38 (TI)	Pembrolizumab (ICI)	Recruiting (2020)
II	NCT04468061	TNBC	SG	Trop-2	SN38 (TI)	Pembrolizumab	Recruiting (2020)
Ib/II	NCT03288545	Urothelial	EV	Nectin-4	MMAE (TI)	Pembrolizumab (ICI)	Recruiting (2017)—FDA breakthrough designation 2019 [177]
I	NCT03310957	Breast	Ladiratuzumab vedotin	LIV-1 (zinc transporter subfamily)	MMAE (TI)	Pembrolizumab (ICI)	Recruiting (2018)
I	NCT03000257	SCLC	Rovalpituzumab tesrine	DLL3	SC-DR002 (DDA)	Budigalimab (PD-LI)	Completed (2019)
I/II	NCT03026166	SCLC	Rovalpituzumab tesirine	DLL3	SC-DR002 (DDA)	Nivo + ipilimumab (ICI)	P1 completed (2018), P2 halted (2019) due to high number of DLTs [178]
I	NCT03639194	SCLC	SC-011	Unknown	DDA	ABBV-181 (ICI)	Recruiting (2018)
I	NCT02099058	NSCLC, solid tumours	Telisotuzumab vedotin	cMET	MMAE (TI)	Nivo	Recruiting (2014)
I	NCT03786081	Cervical	TV	TF	MMAE (TI)	Pembrolizumab	Recruiting (2019)
I	NCT03729596	Advanced solid tumours	MGC018	Anti-B7-H3	Unknown	MGA012 (ICI)	Recruiting (2018)
II	NCT03835819	Endometrial	Mirvetuximab soravtansine	FRα	DM4 (TI)	Pembrolizumab	Recruiting (2019)

cMET: mesenchymal epithelial transition factor; CSA: co-stimulatory agent; DDA: DNA damage agent; DLL3: delta-like ligand 3; FRα: folate receptor alpha; HR⁺: hormone receptor positive; LIV-1: zinc transporter ZIP6/SLC39A6; Nivo: nivolumab; TI: tubulin inhibitor; +: plus

Declarations

Author contributions

SM, SP and HKG contributed to the drafting and editing of the manuscript. SM created the figures. HKG contributed to conception and design of the review. All authors contributed to manuscript revision, read, and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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