Table Info

Table 1.

Pathological impact of Mcl-1 overexpression in cancers

Type of cancer	Pathological impact of Mcl-1 overexpression	References
Prostate	Resistance to therapies and apoptosis	[48, 126]
Breast	Resistance to therapies and apoptosis, contributes to metastasis	[42, 68]
Ovarian	Therapy resistance, poor prognosis	[43, 127]
Renal	Blocks apoptosis	[128]
Lung	Promotes survival and drives lung cancer progression	[14, 129]
Colon	Resistance to targeted therapies and apoptosis	[66, 130]
Pancreatic	Resistance to therapies and apoptosis	[131, 132]
Head and neck	Resistance to therapies, tumor progression, poor prognosis	[15, 133]
Melanoma	Resistance to apoptosis	[105, 134]
MM	Disease relapse, poor prognosis	[135, 136]
AML	Therapy resistance, disease relapse	[18, 137]
NHL	Disease progression, high-grade lymphoma	[138, 139]

MM: multiple myeloma; AML: acute myeloid leukemia; NHL: non-Hodgkin lymphoma

Declarations

Acknowledgment

All the figures were created using the BioRender.com application.

Author contributions

PS reviewed the literature and prepared the manuscript draft. Both authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors have no potential or existing conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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