Registered clinical trials of MSCs in GvHD and HSCT. In this table a number of representable clinical trials are summarized Data were considered as defined in the www.clinicaltrials.gov. Intravenous infusion of MSCs was performed in the listed clinical trials
NCT number
Title
Status
Phase
No of Patients
MSCs Origin
No of MSCs
NCT01956903
Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell
Completed
I/II
15
Allogeneic-MSCs
0.7 × 106 cells/kg – 2.8 × 106 cells/kg
NCT01222039
Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells from Adipose Tissue in Patients With Chronic Graft Versus Host Disease
Completed
I/II
19
Allogeneic-MSCs
1 × 106 cells/kg – 3 × 106 cells/kg
NCT00366145
Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease
Completed
III
260
Undefined
2 × 106 cells/kg
NCT04692376
MSC for Treatment of cGVHD After Allo-HSCT
Recruiting
II
152
Undefined
1 × 106 cells/kg
NCT02824653
Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients with Steroid-refractory GVHD
Completed
I/II
10
Allogeneic-BM-MSCs
Undefined
NCT03106662
Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies
Completed
III
6
Undefined
2.8 × 106 cells/kg
NCT04247945
Co-transplantation of MSC in the Setting of Allo-HSCT
Recruiting
II/III
120
Undefined
Undefined
NCT00823316
Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation
Completed
I/II
10
UCB-MSCs
5 doses of 1 × 106 cells/kg
NCT04692376
MSC for Treatment of cGVHD After Allo-HSCT
Recruiting
II
152
Undefined
8 doses of 8 × 106 cells/kg
NCT00136903
Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease
Completed
II
33
Allogeneic
2 × 106 cells/kg
Declarations
Author contributions
PM wrote the initial draft of the manuscript. EM and TC revised the manuscript. CSG made the final approval for the manuscript.
Conflicts of interest
The authors declare that they have no conflicts of interest.
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