Registered clinical trials of MSCs in SLE, CD, MS and ALS. In this table a number of representable clinical trials are summarized. Data were considered as defined in the www.clinicaltrials.gov
NCT number
Title
Status
Phase
No of patients
MSCs origin
No of MSCs
NCT04184258
Treatment of Systemic Lupus Erythematosus with Pooled Allogenic Mesenchymal Stem Cells
Completed
I/II
7
Pooled-MSCs from olfactory mucosa
Undefined
NCT02633163
Phase 2 Trial of Mesenchymal Stem Cells in Medication-induced Systemic Lupus Erythematosus
Recruiting
II
81
Undefined
1 × 106 cells/kg
NCT03562065
Treatment of Refractory Systemic Lupus Erythematosus by Allogeneic Mesenchymal Stem Cells Derived from the Umbilical Cord
Not yet recruiting
I/II
10
UC-MSCs
1 × 106 cells/kg – 4 × 106 cells/kg
NCT01157650
Treatment of Fistulous Crohn’s Disease by Implant of Autologous Mesenchymal Stem Cells Derived from Adipose Tissue
Completed
I/II
15
Autologous AT-MSCs
Undefined
NCT04519671
Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn’s Disease
Recruiting
I/II
20
Undefined
1 dose of 75 × 106 cells
NCT04519684
Study of Mesenchymal Stem Cells for the Treatment of Ileal Pouch Fistula’s in Participants with Crohn’s Disease
Recruiting
I/II
20
Allogeneic BM-MSCs
1 dose of 75 × 106 cells
NCT01377870
Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis
Completed
I/II
22
Autologous BM-MSCs
Undefined
NCT03778333
Mesenchymal Stem Cells for Progressive Multiple Sclerosis_Sweden
Completed
I
7
Autologous BM-MSCs
1 dose of 1–2 × 106 cells/kg
NCT01759797
Intravenous Transplantation of Mesenchymal Stem Cell in Patients With ALS
Completed
I
6
Autologous BM-MSCs
2 × 106 cells/kg
NCT01051882
Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients
Completed
I/II
12
Neurotrophic factors from autologous BM-MSCs
N/A
Declarations
Author contributions
PM wrote the initial draft of the manuscript. EM and TC revised the manuscript. CSG made the final approval for the manuscript.
Conflicts of interest
The authors declare that they have no conflicts of interest.
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