Table Info

Table 2.

Cases of coexistent LA and anti-FV antibodies [5]

No.	Age (years)	Gender	Underlying conditions	FV:C (%)	FV-inhibitor (BU/mL)	LA	Symptoms	Remarks	Reference
V-1	71	M	Temporo-parietal astrocytoma	< 3	61	dRVVT positive	Left popliteal vein thrombosis	Positive for aCL-IgG and-IgM	Kamphuisen et al. [45]
V-2	29	M	Appendicular infiltrate and antibiotics	23	1	dRVVT positive	No symptoms (abnormal coagulation tests)	None	Van den Berg et al. [46]
V-3	71	F	Hemangiopericytoma, UTI, and antibiotics	1	1.4	dRVVT and Staclot LA positive	Left femoral DVT	None	Donohoe and Levine [47]
V-4	58	M	Unknown	8	2.65	dRVVT positive	DVT	None	Rief et al. [48]
V-5	71	F	Proctoscipyand antibiotics	< 2	6	PNP positive	Ecchymosis and hematoma	None	Sridharan et al. [49]
V-6	63	M	Lithotripsy and antibiotics	2	16	PNP positive	Hematuria	None	Sridharan et al. [49]
V-7	76	F	Pneumonia and antibiotics	2	70	dRVVT positive	Subdural hematoma	None	Olson et al. [50]
V-8	71	F	Pancreatic cancer	< 3	1.7	dRVVT positive	Multiple purpura	None	Yokota et al. [51]
V-9	71	F	HT, HL, and stroke	< 3	8	dRVVT positive	Petechiae, ecchymoses, and melena	Positive for aCL-IgG	Mima et al. [43]
V-10	56	M	HT and DM	2.3	1.9	Staclot LA positive	Purpura and hematuria	None	Ieko et al. [44]
V-11	52	F	SLE and DM	2.5	3	Staclot LA positive	Multiple purpura	None	Ieko et al. [44]

Normal range: FV:C < 60% and anti-FV inhibitor < 1 BU/mL. FV:C: factor V activity; UTI: urinary tract infection; HT: hypertension; HL: hyperlipidemia; DM: diabetes mellitus; DVT: deep vein thrombosis; PNP: platelet neutrization procedure

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/1003103_sup_1.xlsx.

Declarations

Acknowledgments

Thanks are due to Yayoi Ishida of the Health Sciences University of Hokkaido for assistance with this study and Editage (www.editage.com) for the English language editing.

Author contributions

MI: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Funding acquisition, Project administration, Supervision. KO: Data curation, Software. SN: Investigation, Data curation. MY and HS: Investigation. TS and NS: Writing—original draft, Validation. NT: Writing—review & editing, Validation. AI: Writing—review & editing, Funding acquisition, Project administration. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was funded in part by a research grant (to Prof. Akitada Ichinose) for the Japanese Nationwide Survey on Autoimmune Coagulation Factor Deficiencies from the Japanese Ministry of Health, Labor and Welfare [21FC1008]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funder managed this study and helped write and revise this paper.

Copyright

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